The Hematoma Expansion and Increasing Pressure in Traumatic Brain Injuries in the Finite Element Simulation Analysis
1 Hunan University，State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, Changsha 410082, China
2 Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha 410083, China
Abstract：The aims of this study are to develop a threedimensional patientspecific finite element brain model with detailed anatomical structures, and proposed the corpuscular particle method to simulate the cerebral hematoma lead to changes in intracranial pressure. Geometrical data and position of the cerebral hematoma were extracted from a set of medical CT scan images. We used these data to adjust the head model of GHBMC to the geometry of head of patients. Then corpuscular particle method was used to simulate the cerebral hematoma lead to changes in intracranial pressure. Deviation of the cerebral ventricles in the two groups of simulation were 4.6 mm and 5.6 mm, Deviation of the brain midline were 3.7 mm and 3.9 mm, the value of intracranial pressure were stable in 2 680±20 Pa and 2 618±18 Pa. The actual deviation of cerebral ventricles were 4.8 mm and 4.9 mm, The actual deviation of brain midline were 3.7 mm and 3.9 mm, the actual value of intracranial pressure were 2 800 Pa and 2 666 Pa. The data of simulation was in accordance with the actual data. Results showed that the corpuscular particle method was used to simulate analysis of hematoma expansion and intracranial pressure was feasible in theory. This paper can provide the theoretical foundation for the useful clinical application.
曹立波1 傅啸龙1*张冠军1 李娜2. 脑外伤血肿膨胀与颅内压增高的有限元模拟分析[J]. 中国生物医学工程学报, 2015, 34(5): 574-580.
Cao Libo1Fu Xiaolong1* Zhang Guanjun1 Li Na2. The Hematoma Expansion and Increasing Pressure in Traumatic Brain Injuries in the Finite Element Simulation Analysis. journal1, 2015, 34(5): 574-580.
［1］习望，姚志刚，孙晓立，等.持续颅内压监测在高血压脑出血术后的应用 ［J］. 中国医药导刊，2011（10）：1020-1021.
［2］Jackson SA, Piper I, Dunn L, et al.Assessment of the variation of cerebrovasculao reactive in head injured patients ［ J ］. Acta Neurochur (Sup), 2000, 76:445-449.
［3］Bernhard S, Jens JS, Marek C, et al.A method for a simulation of continuous intracranial pressure curves ［ J ］. Computers and Biomedical Research,1998, 3:231 -243.
［4］Eider, Framing. A new Method and Software for Quantitative Analysis of Continuous Intracranial Pressure Recordings ［J］. Acts Neurochirurgica, 2001, 143(12):1237-1247.
［5］Hu J, Jin X, Lee JB, et al. Intraoperative brain shift prediction using a 3d inhomogeneous patient specific finite element model ［J］. Journal of Neurosurgery, 2007106(1):164-169.
［6］岳献芳，王立，周峰，等.颅骨和硬脑膜随颅内压变化的粘弹性有限元分析 ［J］. 中国生物医学工程学报，2007，26（4）：556-560.
［7］岳献芳，王立，周峰，等.颅内压变化引起的颅骨表面应变分析 ［J］. 北京科技大学学报，2006，28（12）：1144-1150.
［8］Mao Haojie, Zhang Liying, Jiang Binhui, et al. Development of a finite element human head model validated with thirty-five loading cases from experimental and real world impacts［J］. Journal of Biomechanical Engineering, 2013,(135):1-12.
［9］Olovssn L. Corpuscular method for airbag deployment simulation in LSDYNA［C］//The 6th European LSDYNA Users Conference. Gothenburg:ERAB,2007(4)：61-70.
［10］吴光强，吴奕娴，等.汽车安全气囊展开过程的仿真算法 ［J］. 同济大学学报：自然科学版，2012,40（2）：281-285.
［11］万鑫铭,杨济匡.基于虚拟试验方法的气囊折叠方式对离位乘员损伤影响的研究［J］.汽车工程,2005,27(6):682-686.
［12］Yeh I, Chai L, Saha N. Application of ALE to airbag deployment simulation ［J］. International Journal of Vehicle Safety. 2006 (4)：348-365.
［13］汪娜，彭雄奇，张源，等.基于颗粒法的安全气囊仿真及应用分析 ［J］. 上海交通大学学报, 2014, 48(8): 1079-1083.
［14］江基尧.现代颅脑损伤学 ［M］.3版.上海：第二军医大学出版社.2010：138.
［15］董勇.颅内压监护下治疗急性颅内血肿55例分析［D］.杭州:浙江大学,2007:1-9.
［16］邱海波. ICU 监测与治疗技术［M］.上海：上海科学技术出版社, 2009:318.
［17］崔荣周，詹彦，谢延风，等.持续动态颅内压监测在矢状窦、大脑镰旁大型脑膜瘤术后的意义 ［J］. 第三军医大学学报，2011，33（15）：1626-1628.
