Research Progress in Study of Tissue Engineering Scaffolds and their Pore Morphologies by Supercritical CO2 Foaming Technology
1 College of Chemical Engineering Department of Bioengineering and Technology, Huaqiao University, Xiamen 361021, China
2 Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China
Abstract：As a carrier for the cell growth, tissue engineering scaffolds play important roles in the development of tissueengineered tissue. Conventional methods have been widely studied in manufacture of threedimension scaffolds. However, there are still some obstacles, such as the complication in process, removing organic solvents completely and maintaining the bioactivity of biomolecules loaded. Due to its environmentfriendship and high diffusion rate, the supercritical carbon dioxide (scCO2) technology, particularly the supercritical foaming process, has been widely exploited for producing tissue engineering scaffolds. The pore morphologies of the resulting scaffolds are largely dependent on physical and chemical parameters including the chemical composition, porogen and processing parameters. This article mainly reviews the development of tissue engineering scaffolds and the study of their pore morphologies by supercritical CO2 foaming technology. Advices regarding existing problems and prospective research are also proposed.
马腾1 陈爱政1王士斌1,2*. 超临界二氧化碳流体发泡技术制备组织工程支架及其泡孔形貌控制研究进展[J]. 中国生物医学工程学报, 2014, 33(4): 467-474.
MA Teng1 CHEN Ai Zheng1 WANG Shi Bin1,2*. Research Progress in Study of Tissue Engineering Scaffolds and their Pore Morphologies by Supercritical CO2 Foaming Technology. journal1, 2014, 33(4): 467-474.
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