Brain Electrical Source Analysis of EventRelated Potentials in Depressive Disorder
1 College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen, 518060, China
2 Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
3 College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China
Abstract：Using visual threestimulus oddball paradigm, activities of cortical current sources elicited by target and distractor stimuli were investigated in depressive patients. The 64-channel EEG signals were recorded in healthy subjects and depressed patients during the task. A regional source model with constraints of spatial coordinates from fMRI BOLD clusters was applied to eventrelated potentials (ERPs) data in the target and distractor conditions. The reconstructed source activities were sent to unpaired t-test and permutation test, statistical results indicated source activities in the right insular and right precentral sulcus in the late phase of P300 show significant difference between patients and healthy controls in the target condition, and scalp voltage maps projected by the current flow direction of corresponding regional sources in patients show abnormal negative potential over the right prefrontal scalp area. It was also found that source activity in the left precentral sulcus in the late phase of P300 showed significant difference at a trend level (P=0.087) in the distractor condition. Scalp voltage map showed abnormal nearzero potential over the left prefrontal area.
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