缝合式和机械吻合式搭桥模型的血流动力学数值模拟

doi:10.3969/j.issn.0258-8021.2012.06.010

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摘要为了说明机械吻合器的引入对冠状动脉搭桥术近端吻合区血流动力学因素的影响，运用Solidworks软件构造了缝合式和机械吻合式两种搭桥模型。运用有限单元数值模拟的方法和Fluent6.3软件,对两种模型移植血管中脉动流进行数值化模拟和可视化分析。获得了吻合区在一个心动周期内不同时刻的速度场、二次流、压力及壁面切应力的分布情况。结果表明，机械吻合器的引入在增大移植血管中血流速度（大于缝合模型约0.2 m/s）的同时使得低速区范围增大，吻合区壁面切应力变化范围为0～50 Pa，应力集中现象明显，壁面切应力变化剧烈，易引起血小板活化和内膜增生。为了提高冠状动脉搭桥术的通畅率，对机械吻合器进行优化设计很有必要。

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	高进涛王国栋肖聚亮^*

关键词 ：冠状动脉搭桥, 机械吻合, 脉动流, 血流动力学, 数值模拟

Abstract：In order to clarify the influence of the sutureless anastomotic devices on hemodynamic factors in proximal anastomosis in coronary artery bypass graft (CABG), suturing and sutureless anastomotic models were constructed by software Solidworks. The pulsatile flows in the two models were simulated and analyzed with finite element method and software Fluent 6.3. The distribution of velocity, second flow, pressure and wall shear stress were calculated with a function of time in a cardiac cycle. Results showed that using the sutureless anastomotic devices enlarged the area of low velocity, which was 0.2 m/s higher than suturing model, while increased the magnitude of the velocity in grafts. The wall shear stress in anastomosis ranged from 0 to 50 Pa and changed dramatically, besides, stress concentration was more serious in sutureless anastomotic model, which would lead to the activation of the platelets and intimal hyperplasia. Optimal design of sutureless anastomotic devices is necessary for the improvement of CABG patency rates.

Key words： coronary artery bypass graft sutureless anastomosis pulsatile flow hemodynamics numerical simulation

引用本文:

高进涛王国栋肖聚亮^*. 缝合式和机械吻合式搭桥模型的血流动力学数值模拟[J]. 中国生物医学工程学报, 2012, 31(6): 866-874.
GAO Jin Tao WANG Guo Dong XIAO Ju Liang^*. Numerical Simulation of Hemodynamics in Suturing and Sutureless Anastomotic Models. journal1, 2012, 31(6): 866-874.

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http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2012.06.010 或 http://cjbme.csbme.org/CN/Y2012/V31/I6/866

［1］Riess FC, Helmold H, Hilfer I，et al. Clinical experience with the CorLink device for proximal anastomosis of the saphenous vein to the aorta: A clinical, prospective, and randomized study［J］. The Heart Surgery Forum,2002,5(4):345-353.
［2］Sun Anqiang, Fan Yubo, Deng Xiaoyan, et al. Hemodynamic performance of a sutureless anastomosis device (the Graft Connector): a numerical study［J］. Int J Artif Organs, 2010,33(6):392-398.
［3］Dohmen G, Hatama N, Goetzenich A, et al. PASPort clampless proximal anastomotic device for coronary bypass surgery in porcelain aorta［J］. European Journal of Cardiothoracic Surgery, 2011,39(1):49-52.
［4］Gummert JF, Opfermann U, Jacobs S, et al. Anastomotic devices for coronary artery bypass grafting: Technological options and potential pitfalls［J］.Computers in Biology and edicine,2007,37(10):1384-1393.
［5］Zhang JM, Chua LP, Ghista DN, et al. Numerical investigation and identification of susceptible sites of atherosclerotic lesion formation in a complete coronary artery bypass model［J］. Med Biol Eng Comput, 2008,46(7): 689-699.
［6］乔爱科，刘友军.股动脉双路搭桥的血流动力学仿真［J］.中国生物医学工程学报，2006,25(2):211-218.
［7］Milner JS, Moore JA, Rutt BK, et al. Hemodynamic of human carotid artery bifurcations: computational study with models reconstructured from magnetic resonance imagining of normal subjects［J］. Journal of Vascular Surgery,1998,281):143-156.
［8］Shaik E, Hoffmann KA, Dietiker JF. Numerical simulations of pulsatile NonNewtonian flow in an endtoside anastomosis model［J］. Simulation Modeling Practice and Theory, 2008,16(9):1123-1135.
［9］Chua LP, Zhang JM, Yu SC, et al. Numerical study on the pulsatile flow characteristics of proximal anastomotic model［J］. Proc Inst Mech Eng, 2005,219(5):361-379.
［10］Chua LP, Ji Wenfa, Zhou Tongming. In vitro study on the steady flow characteristics of proximal anastomotic models［J］. International Communications in Heat and Mass Transfer, 2005,32(3-4):464-472.
［11］Redaelli A, Maisano F, Ligorio G, et al. Flow dynamics of the St Jude Medical Symmetry aortic connector vein graft anastomosis do not contribute to the risk of acute thrombosis ［J］. Journal of Thoracic and Cardiovascular Surgery, 2004, 128(1):117-123.
［12］杨俊勇.心血管系统(主动脉弓)血液流场计算［D］.杭州：浙江理工大学,2008.
［13］林亚华，景在平，赵志清，等.人胸主动脉血液脉动流的三维数值分析［J］.第二军医大学学报，2006,27(8):867-875.
［14］李言芝. B型主动脉夹层血液流动数值模拟分析［D］. 兰州：兰州理工大学,2011.
［15］Chua LP, Zhang JM, Zhou TM. Numerical study of a complete anastomosis model for the coronary artery bypass［J］.Heat and Mass Tranf, 2005,32(3):473-482.
［16］邱霖，岑人经.有锥度角的主动脉弓血液脉动流数值分析［J］.医用生物力学,2004,19(2):74-78.
［17］刘有军，乔爱科，黄伟.冠状动脉移植管的血流动力学数值模拟［J］.中国生物医学工程学报，2004,23(4):370-377. 
［18］叶显华，徐鹏，王宁夫，等.高血压对冠心病血小板活化作用的影响［J］.心脑血管病防治，2011,11(1):27-28.
［19］乔爱科，刘有军，李晓阳. 股动脉对称搭桥术的数值分析［J］.北京工业大学学报，2006,32(4):363-36.
［20］姜宗来. 生物力学：我国生物力学研究现状与展望［J］. 中国生物医学工程学报，2011, 30(2):161-168.

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