用于体外循环管材的新型醛基化海藻酸钠-地塞米松缓释涂层研究

doi:10.3969/j.issn.0258-8021.2014. 06.014

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Abstract The aim of this work is to prepare a novel composite coating of sodium alginate and dexamethasone. By optimizing the coating mode and conditions, the properties of stability, anticoagulation and controlled release were evaluated. Polyethyleneimine (PEI) was coated on PVC pipelines surface pretreated with acidification, dexamethasone sodium phosphate (DSP) was coated on PEIcoated pipelines (PP) with ionic bond, DSP coated pipelines were created (Group PPD). Pipelines coated OSADXM composite were created by ionic bond (Group PPI) or covalent bond (Group PPC). The control group (Group C) was set as well. The optimum coating condition was obtained by the orthogonal test. By evaluating the properties of different coated pipelines including anticoagulation, platelet adhesion, protein adhesion and release in vitro, the optimum coating mode was determined. DSP can be bound to PVC surface in Group PPD, PPI and PPC. The optimum immobilization quantity of DSP on different groups are (333±075)，(163±076)，(206±068) μg/cm2. The platelet adhesion (109/L) of Group PPI and PPC (1388±189 and 1913±340) was significantly reduced than that of Group C (4138±320). The protein adhesion (mg/cm2) of Group PPI and PPC (HAS: 2986±1357 and 4667±320, HPF: 3499±352 and 4567±379) was significantly decreased than that of Group PPD (Has: 6873±426, HPF: 7254±790). The release property of Group PPC is superior to that of Group PPI. The coating of OSADXM composite exhibited improved hemocompatibility. Covalently bound DSP can be controlled released.
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Key words： dexamethasone sodium phosphate sodium alginate controlled release biocompatibility hemocompatibility

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	GAO Wen Qing¹ LI Tong^1* YU Mei Li² HU Xiao Min¹DUAN Da Wei¹

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GAO Wen Qing¹ LI Tong^1* YU Mei Li² HU Xiao Min¹DUAN Da Wei¹. Research on a Novel Sodium AlginateDexamethasone Composite Coating with MultiAldehyde Groups Applied to Extracoporeal Circuits#br#[J]. journal1, 2014, 33(6): 737-745.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2014. 06.014 OR http://cjbme.csbme.org/EN/Y2014/V33/I6/737

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