Abstract The aim of this work is to prepare a novel composite coating of sodium alginate and dexamethasone. By optimizing the coating mode and conditions, the properties of stability, anticoagulation and controlled release were evaluated. Polyethyleneimine (PEI) was coated on PVC pipelines surface pretreated with acidification, dexamethasone sodium phosphate (DSP) was coated on PEIcoated pipelines (PP) with ionic bond, DSP coated pipelines were created (Group PPD). Pipelines coated OSADXM composite were created by ionic bond (Group PPI) or covalent bond (Group PPC). The control group (Group C) was set as well. The optimum coating condition was obtained by the orthogonal test. By evaluating the properties of different coated pipelines including anticoagulation, platelet adhesion, protein adhesion and release in vitro, the optimum coating mode was determined. DSP can be bound to PVC surface in Group PPD, PPI and PPC. The optimum immobilization quantity of DSP on different groups are (333±075)，(163±076)，(206±068) μg/cm2. The platelet adhesion (109/L) of Group PPI and PPC (1388±189 and 1913±340) was significantly reduced than that of Group C (4138±320). The protein adhesion (mg/cm2) of Group PPI and PPC (HAS: 2986±1357 and 4667±320, HPF: 3499±352 and 4567±379) was significantly decreased than that of Group PPD (Has: 6873±426, HPF: 7254±790). The release property of Group PPC is superior to that of Group PPI. The coating of OSADXM composite exhibited improved hemocompatibility. Covalently bound DSP can be controlled released.
GAO Wen Qing1 LI Tong1* YU Mei Li2 HU Xiao Min1 DUAN Da Wei1. Research on a Novel Sodium AlginateDexamethasone Composite Coating with MultiAldehyde Groups Applied to Extracoporeal Circuits#br#[J]. journal1, 2014, 33(6): 737-745.
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