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The Significance of Macrophage Phenotype in Injury as well as the Biomaterials Inducing Tissue Repair and Regeneration |
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Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College, Beijing 100005, China |
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Abstract The body inflammatory reaction is a normal response to injury and the presence of foreign substances.The duration and intensity of inflammation has a direct impact on biocompatibility and stability of biomaterials in vivo.Macrophage is one of the major cell types in controlling body inflammatory and immune processes,hence,its response to biomaterials is critical for identifying the biomaterialbody reaction.In this review, the correlation between macrophage phenotype and injury as well as the tissue repair or regeneration,the interaction of macrophages with biomaterials, and the future development are introduced in detail.
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