低温保护剂渗透关节软骨研究进展

doi:10.3969/j.issn.0258-8021.2015. 04.013

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Abstract Vitrification of articular cartilage (AC) has excited great interest due to the clinical and scientific significances of this tissue. Sufficient permeation throughout the tissue and minimization of accompanying damage to cells are required for successful vitrification of AC. The knowledge of permeation kinetics of cryoprotectant (CPA) in AC is important for designing the CPA addition protocol. In this review, developments on the permeation of CPA into AC are summarized from two aspects: measurement of CPA diffusion in AC and mathematical modeling of CPA transport in AC. A great of efforts have been made, which has led to the recent advancements in the field, but more investigations still deserved to be addressed, such as copermeation of multiple CPAs into AC, CPA permeation at subzero temperatures, and strengthening of CPA transport.

Key words： articular cartilage cryoprotectant permeation diffusion mathematical modeling

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	Yu Xiaoyi¹Zhang Shaozhi²Fan Juli³Hu Changxing^{1 *}

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Yu Xiaoyi¹Zhang Shaozhi²Fan Juli³Hu Changxing^{1 *}. A Review of Cryoprotectant Permeation into Articular Cartilage[J]. journal1, 2015, 34(4): 481-486.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2015. 04.013 OR http://cjbme.csbme.org/EN/Y2015/V34/I4/481