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| Recent Advances in the UltrasoundMediated Drug Delivery Systems |
1 College of Chemistry, Chemical Engineering ＆ Biotechnology, Donghua University，Shanghai 201620, China
2 School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore |
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Abstract Ultrasound-controlled drug delivery systems have emerged as a new method in the field of targeted drug delivery and gene transfer. Under ultrasound radiation, drug-loaded or gene transfer depots made of ultrasound-sensitive materials, are able to release genes or drugs on-demand, thus improving temporospatial control in drug delivery and gene transfection efficiency. This article reviews the recent advances in ultrasound-controlled drug delivery systems including the mechanism of ultrasoundmediated drug delivery, ultrasound-sensitive drug- and/or gene-loaded carriers, and biomedical applications. Finally, the existing problems and future trends in this niche area are discussed as well.
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