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Recent Advances in the UltrasoundMediated Drug Delivery Systems |
1 College of Chemistry, Chemical Engineering & Biotechnology, Donghua University,Shanghai 201620, China
2 School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore |
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Abstract Ultrasound-controlled drug delivery systems have emerged as a new method in the field of targeted drug delivery and gene transfer. Under ultrasound radiation, drug-loaded or gene transfer depots made of ultrasound-sensitive materials, are able to release genes or drugs on-demand, thus improving temporospatial control in drug delivery and gene transfection efficiency. This article reviews the recent advances in ultrasound-controlled drug delivery systems including the mechanism of ultrasoundmediated drug delivery, ultrasound-sensitive drug- and/or gene-loaded carriers, and biomedical applications. Finally, the existing problems and future trends in this niche area are discussed as well.
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[1]Choi S W, Zhang Y, Xia YA. TemperatureSensitive drug release system based on phasechange materials [J]. Angew Chem Int Ed, 2010, 49(43): 7904-7908.
[2]Kim KT, Cornelissen K. A Polymersome nanoreactor with controllable permeability induced by stimuliresponsive block copolymers [J]. Adv Mater, 2009, 21(27): 2787-2791.
[3]Dvir T, Banghart MR, Timko BP. PhotoTargeted Nanoparticles [J]. Nano Lett, 2010, 10(1): 250-254.
[4]Chakravarty P, Qian W, EISayed MA. Delivery of Molecules into Cells Using Carbon Nanoparticles Activated by Femtosecond Laser Pulses [J]. Nature Nanotechnology, 2010, 5: 607-611.
[5]Kulkarni RV, Biswanath S. Electrically responsive smart hydrogels in drug delivery: a review [J]. J Appl Biomater Biomech, 2007, 5(3): 125-139.
[6]Namiki Y, Namiki T, Yoshida H. A novel magnetic crystal lipid nanostructure for magnetically guided in vivo Gene Delivery [J]. Nat Nanotechnol, 2009, 4(23): 598-606.
[7]Alexander M, Natalya R. Mechanism of the ultrasonic activation of micellar drug delivery [J]. Journal of Controlled Release, 2001, 75(1): 69-81.
[8]Kennedy JE, Cranston D. High intensity focused ultrasound: surgery of the future? [J]. Br J Radiol, 2003, 76: 590.
[9]Victor Frenkel. Ultrasound mediated delivery of drugs and genes to solid tumors [J]. Advanced Drug Delivery Reviews, 2008, 60: 1193-1208.
[10]Kost J, Leong K, Langer R. Ultrasoundenhanced polymer degradation and release of incorporated substances [J]. Proc Natl Acad Sci, 1989, 86(20): 7663-7666.
[11]Huang Shaoling. Liposomes in ultrasonic drug and gene delivery [J]. Advanced Drug Delivery Reviews, 2008, 60(10): 1167–1176.
[12]Lin HY, Thomas JL. PEGlipids and oligo (ethylene glycol) surfactants enhance the ultrasonic permeabilizability of liposomes [J]. Langmuir, 2003, 19(4): 1098-1105.
[13]Klibanov AL, Shevchenko TI, Raju BI, et al. Ultrasoundtriggered release of materials entrapped in microbubbleliposome constructs: a tool for targeted drug delivery [J], Journal of Controlled Release, 2010, 148(1): 13-17.
[14]Zhang Hongji, Xia Hesheng, Wang jie, et al. High intensity focused ultrasoundresponsive release behavior of PLAbPEG copolymer micelles [J]. Journal of Controlled Release, 2009, 139(1): 31-39.
[15]Husseini G, Pitt W. Ultrasonicactivated micellar drug delivery for cancer treatment [J]. J Pharm Sci, 2009, 98(3): 795-811.
[16]Stuart I, Michael B, Dmitri S, et al. A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload [J]. Journal of Controlled Release, 2011, 155(3): 358-366.
[17]Skirtach AG, Mamedov AA. Ultrasoundtriggered release from multilayered Capsules [J]. Small, 3(5): 804-808
[18]Jing Yujia, Zhu Yihua, Yang Xiaoling, et al. Ultrasoundtriggered smart drug release from multifunctional coreshell capsules onestep fabricated by coaxial electrospray method [J]. Langmuir, 2011, 27 (3): 1175-1180
[19]Skirtach AG, De Geest BG, Mamedov A, et al. Ultrasound stimulated release and catalysis using polyelectrolyte multilayer capsules [J]. Journal of materials chemistry, 2007, 17 (11): 1050-1054.
[20]Ferrara KW.. Driving delivery vehicles with ultrasound [J]. Advanced drug delivery reviews, 2008, 60(10): 1097-1102.
[21]Daisuke K, Hideyuki M, Chiaki K. Effect of reactor’s positions on polymerization and degradation in an ultrasonic field [J]. Ultrasonics sonochemistry, 2008, 15(3): 251-256.
[22]Dennis L, Erik CG, Dennis M. et al. Vriezema biodegradable polymeric microcapsules for selective ultrasoundtriggered drug release [J]. Soft Matter, 2011, 7(11): 5417-5422.
[23]Hwang JH, Brayman AA, Reidy MA, et al. Vascular effects induced by combined 1MHz ultrasound and microbubble contrast agent treatments in vivo [J]. Ultrasound ed Biol, 2005, 31(4): 553-564.
[24]Husseini GA, de la Rosa MAD, Gabuji T, et al. Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound [J]. J Nanosci Nnotechnol, 2007, 7(3): 1028-1033.
[25]Marin A, Sun H, Husseini GA, et al. Drug delivery in pluronic micelles: effect of highfrequency ultrasound on drug release from micelles and intracellular uptake [J]. J Control Release, 2002, 84(1-2): 39-47.
[26]Niemczewski B. A comparison of ultrasonic cavitation intensity in liquids [J], Ultrasonics, 1980, 18(3): 107-110.
[27]Li Weiyang, Cai Xin, Kim C, et al. Gold nanocages covered with thermallyresponsive polymers for controlled release by highintensity focused ultrasound release by highintensity focused ultrasound [J]. Nanoscale, 2011, 3(4): 1724-1730.
[28]Kost J, Leong K, Langer R. Ultrasoundenhanced polymer degradation and release of incorporated substances [J]. Proc Natl Acad Sci USA, 1989, 86(20): 7663-7666.
[29]Liu LS, Kost J, Langer R, et al. Experimental approach to elucidate the mechanism of ultrasoundenhanced polymer erosion and release of incorporated substances [J]. Macromolecules, 1992, 25(1): 123-128.
[30]Kost J, Liu LS, Gabelnick H, et al. Ultrasound as a potential trigger to terminate the activity of contraceptive delivery implants [J]. J Control Release, 1994, 30(1): 77-81.
[31]Lavon I, Kost J. Mass transport enhancement by ultrasound in nondegradable polymeric controlled release systems [J]. J Control Release, 1998, 54(1): 1-7.
[32]Husseini GA, Myrup GD, Pitt WG, et al. Factors affecting acoustically triggered release of drugs from polymeric micelles [J]. J Control Release, 2000,69(1): 43-52.
[33]Rapoport NY, Christensen DA, Fain HD, et al. Ultrasoundtriggered drug targeting of tumors in vitro and in vivo [J], Ultrasonics, 2004, 42(1-9): 943-950.
[34]Suzuki R, Takizawa T, Negishi Y, et al. Tumor specific ultrasound enhanced gene transfer in vivo with novel liposomal bubbles [J], J Control Release, 2008, 125(2): 137-144.
[35]Evjen TJ, Nilssen EA, Rgnvaldsson S, et al. Distearoylphosphatidylethanolaminebased liposomes for ultrasoundmediated drug delivery [J]. European Journal of Pharmaceutics and Biopharmaceutics, 2010, 75(3): 327-333.
[36]Norris P, Noble M, Francolini I, et al. Ultrasonically controlled release of ciprofloxacin from selfassembled coatings on poly(2hydroxyethyl methacrylate) hydrogels for pseudomonas aeruginosa biofilm prevention [J]. Antimicrob Agents Chemother, 2005, 49(10): 4272-4279.
[37]Kwok CS, Mourad PD, Crum LA, et al. Selfassembled molecular structures as ultrasonicallyresponsive barrier membranes for pulsatile drug delivery [J]. Journal of Biomedical Materials Research, 2001, 57(2): 151–164.
[38]Gao Z, Fain H, Rapoport N. Controlled and targeted tumor chemotherapy by micellarencapsulated drug and ultrasound [J]. J Control Release, 2005, 102(1): 203-222.
[39]Lentacker I, Vandenbroucke RE, Peeters L, et al. Ultrasoundresponsive polymercoated microbubbles that bind and protect DNA [J]. Langmuir, 2006, 22(17): 7273-7278.
[40]Kooiman K, Boehmer MR, Emmer M, et al. Oilfilled polymer microcapsules for ultrasoundmediated delivery of lipophilic drugs [J]. J Control Release, 2009, 133(2): 109-118.
[41]Du L, Jin Yiguang, Zhou Wenying, et al. UltrasoundTriggered DrugRelease and Enhanced Anticancer Effect of DoxorubicinLoaded Poly(D,LLactideCoGlycolide)-MethoxyPoly(Ethylene Glycol) Nanodroplets [J]. Ultrasound in Medicine & Biology, 2011, 37(8): 1252-1258.
[42]Yudina A, de Smet M, LepetitCoiffé M, et al. Ultrasoundmediated intracellular drug delivery using microbubbles and temperaturesensitive liposomes [J]. J Control Release, 2011, 155: 442-448.
[43]Wan C, Jackson JK, Pirmoradi FN, et al. Increased Accumulation and Retention of Micellar Paclitaxel in DrugSensitive and PGlycoproteinExpressing Cell Lines Following Ultrasound Exposure [J]. Ultrasound in Medicine & Biology, 2012, 38(5): 736-744.
[44]Bao Min, Zhou Qihui, Dong Wen, et al. UltrasoundModulated Shape Memory and Payload Release Effects in a Biodegradable Cylindrical Rod Made of ChitosanFunctionalized PLGA Microspheres [J]. Biomacromolecules, 2013, 14(6): 1971-1979.
[45]Li Guo, Fei Guoxia, Xia Hesheng, et al. Spatial and temporal control of shape memory polymers and simultaneous drug release using high intensity focused ultrasound [J]. J Mater Chem, 2012, 22(16): 7692-7696.
[46]Negishi Y., Matsuo K, EndoTakahashi Y, et al. Delivery of an Angiogenic Gene into Ischemic Muscle by Novel Bubble Liposomes Followed by Ultrasound Exposure [J]. Pharmaceutical Research, 2011, 28(4): 712-719.
[47]Beeri R, Guerrero JL, Supple G, et al. New Efficient CatheterBased System for Myocardial Gene Delivery [J]. Circulation, 2002, 106: 1756-1759.
[48]RV Shohet, S Chen, YT Zhou, et al. Echocardiographic Destruction of Albumin Microbubbles Directs Gene Delivery to the Myocardium [J]. Circulation, 2000, 101: 2554-2556.
[49]Christiansen JP, LeongPoi H, Klibanov AL, et al. Noninvasive Imaging of Myocardial Reperfusion Injury Using LeukocyteTargeted Contrast Echocardiography [J]. Circulation, 2002,105: 1764-1767.
[50]Anwer K, Kao G, Proctor B, et al. Ultrasound enhancement of cationic lipidmediated gene transfer to primary tumors following systemic administration [J]. Gene Therapy, 2000, 7(21): 1833-1839.
[51]Manome Y, Nakayama N, Nakayama K, et al. Insonation facilitates plasmid DNA transfection into the central nervous system and microbubbles enhance the effect [J]. Ultrasound Med Biol, 2005, 31(5): 693-702.
[52]Rapoport N, Gao Z, Kennedy A, et al. Multifunctional Nanoparticles for Combining Ultrasonic Tumor Imaging and Targeted Chemotherapy [J]. J Natl Cancer Inst, 2007, 99 (14): 1095-1106.
[53]Bekeredjian R,Chen S,Frenkel PA,et al. Ultrasoundtargeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart [J].Circulation, 2003, 108(8): 1022.
[54]Rawool NM, Goldberg BB, Goldberg, MD, et al. Power doppler assessment of vascular changes during fracture treatment with lowintensity ultrasound [J]. J of Ultrasound in Medcine, 2003, 22(2): 145-153.
[55]Rubin, C, Bolander, M, Ryaby C, et al. The use of low intensity ultrasound to accelerate the healing of fractures [J]. The Journal of Bone & Joint Surgery, 2001, 83(2): 259-264.
[56]Ryaby JT, Bachner EJ, Bendo JA, et al. Low intensity pulsed ultrasound increases calcium incorporation in both differentiating cartilage and bone cell cultures [J]. Trans Orthop Res Soc, 1989, 14: 15-21.
[57]Ryaby JT, Mathew J, DuarteAlves P. Low intensity pulsed ultrasound affects adenylate cyclase activity and TGF-β synthesis in osteoblastic cells [J]. Trans Orthop Res Soc, 1992, 256: 284-287.
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