聚乳酸生物可吸收支架在静态和动态系统中降解行为的研究

doi:10.3969/j.issn.0258-8021. 2014. 04.09

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Abstract In this study, static and dynamic degradation systems were set up to understand the degradation behaviors of PLLA (polyllactic acid）bioresorbable scaffolds (BRS) between the two systems. GPC and MDSC methods were employed to characterize molecular weight and thermodynamic properties of the material. Surface morphology, mass loss, diameter and radial strength of BRS were evaluated by scanning electron microscope (SEM), electronic balance, noncontact measurement system and radial force tester, respectively. The results showed that molecular weight (Mw) of the BRS kept dropping in static and dynamic systems with increasing degradation time, and it was reduced to 61.7% and 68.5% of their original Mw_(0) respectively after six months, but there were no significant differences between the two systems. Polydispersity index（PDI）of PLLA in the dynamic system was larger than that in the static system, suggesting inhomogeneous degradation in the dynamic degradation system. Thermodynamic properties, the surface morphology and the changes of outside diameters（OD）as well as the radial strengths were quite similar in the two systems. Based on these results, the complex dynamic degradation system could be replaced by the static degradation system for studying degradation behaviors of PLLA BRS products within 6 months.

Key words： bioresorbable scaffolds static degradation dynamic degradation

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2014. 04.09 OR http://cjbme.csbme.org/EN/Y2014/V33/I4/447

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