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| Comparison and Measurement of Plaque Heights for Carotid FlowMediated Dilation Based on Ultrasound Phantom |
1 Department of Biomedicine Engineering, College of Life Science and Technology,“Image Processing and Intelligence Control” Key Laboratory of Education Ministry of China, Huazhong University of Science and Technology, Wuhan 430074, China
2 Sun YatSen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China
3 Institute for Pattern Recognition and Artificial Intelligence (IPRAI), State Key Laboratory for Multispectral Information Processing Technologies, Huazhong University of Science and Technology, Wuhan 430074, China
4 The Fifth Affiliated Hospital of Zhengzhou University CTroom, Zhengzhou 450052, China
5 Department of Urology, Union Hospital, Tongji Medicinal College, Huazhong University of Science and Technology, Wuhan 430074, China |
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Abstract The aim of this study was to find the most efficient measurement method used for the early diagnosis and treatment of carotid atherosclerosis in clinic. Measurement experiments based on the ultrasound phantom were designed to obtain the plaque heights for flowmediated dilation (FMD). The quantitative analysis and comparison were made among these methods. Actual heights of simulated plaques in carotid ultrasoundphantom were used as the golden standard of the measurement. Measurement experiments for the plaques heights were designed for FMD evaluation. Plaque height measurements were implemented on two individual software of ultrasonographybased specialized software (USS) and our developed segmentation software (OSS), with three different measurement methods: transverse direct measurement (or transverse plaques height measurement, TPHM); transverse indirect measurement (or transverse plaques area measurement, TPAM); longitudinal direct measurement (or longitudinal plaques height measurement, LPHM). The measurement methods were evaluated according to the plaques heights. The measurement results between USS and OSS were statistically and significantly different (P<0.05), but the means of their difference are less than 0.02 cm with three different plaque heights. For TPAM, USS has a better performance on accuracy than OSS while for TPHM and LPHM, the conclusions were opposite. In conclusion, results obtained from the two measurements are both close to the golden standard, while the accuracy of OSS is higher than the USS.
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