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| Research Progress of Biological 3D Printing Strategy in Three-Dimensional Tissue Constructionof Functionalized Skeletal Muscle |
| Zhang Feihu1, Li Ting2,3,4, Lin Zhiwei1, Li Yanbing2,3,4, Huang Wenhua1,2,3,4* |
1(Department of Basic Medical Sciences/Department of Human Anatomy and Tissue Embryology, Guangdong Medical University, Dongguan 523808, Guangdong,China)
2(State Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515,China)
3(Guangdong Provincial Key Laboratory of Medical Biomechanics, Guangzhou 510515, China)
4(Guangdong Medical 3D Printing Application Translational Engineering Technology Research Center, Guangzhou 510515, China) |
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Abstract Skeletal muscle is essential for body movement, and loss of motor function due to volumetric muscle loss (VML) can limit the ability to move. Transplant surgery is the main clinical approach, however, is still limited by the morbidity of the donor site, the lack of donor tissue, and the need for a highly skilled surgical team. Biological 3D printing technology provides a more efficient and accurate method for the manufacture of functional muscles, and a feasible method for the regeneration and repair of VML muscles. This paper reviewed the research status of biological 3D printing technology in the construction of functional skeletal muscle tissue structure, as well as research progress of biological 3D printing and biological ink in functional muscle structures, mainly focusing on the construction of vascularized and neuralized skeletal muscle biomimetic tissue. The effects of various functional skeletal muscle structures constructed by 3D printing on the repair of skeletal muscle defects were summarized. Finally, development trends and existing limitations in the field were proposed.
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Received: 18 April 2023
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Corresponding Authors:
*E-mail: huangwenhua2009@139.com
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