纳米药物递送在脑缺血再灌注损伤中对炎症反应和氧化应激的治疗及其进展

doi:10.3969/j.issn.0258-8021.2023.02.012

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Abstract Stroke is the second leading cause of death worldwide, 80 % of which is ischemic stroke. Reperfusion injury including inflammation, oxidative stress etc. is the key to prognosis of cerebral ischemia. Recently, functionalized nano-drug delivery systems,are widely applied in the cerebral ischemia for their characteristics of biocompatibility, tractability, and strong specificity. This paper reviews the research progresses on metal nano-delivery systems, biocompatible nano-delivery systems, and polymer nano-delivery systems that inhibit inflammatory responses and eliminate oxidative stress in the ischemia/reperfusion injury. The future development prospects of nano drug-delivery systems are proposed as well.

Key words： nanomedicine delivery cerebral ischemia-reperfusion injury inflammation oxidative stress polymeric nanoparticle

Received: 26 October 2021

PACS:

R318

Corresponding Authors: ^*E-mail: pqlpzy@cqmu.edu.cn

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	Xiao Xinyu
	Gao Yu
	Jiang Ning
	Peng Qiling

Cite this article:

Xiao Xinyu,Gao Yu,Jiang Ning, et al. Advances and Perspectives of Nano-Drug Delivery Systems Targeting Inflammation and Oxidative Stress during Cerebral Ischemia-Reperfusion Injury[J]. Chinese Journal of Biomedical Engineering, 2023, 42(2): 235-241.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2023.02.012 OR http://cjbme.csbme.org/EN/Y2023/V42/I2/235

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