光热疗法中热休克蛋白的抑制策略及其研究进展

doi:10.3969/j.issn.0258-8021.2023.02.011

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Abstract Photothermal therapy (PTT) can kill tumor cells accurately and efficiently by using photothermal agents under the irradiation of external light source, so it has a broad application prospect in the treatment of solid tumors. However, recent studies have observed that PTT may lead to abnormal upregulation of heat shock proteins (HSPs) in the cells, which enhances the heat resistance of cells and affects the therapeutic effect. Aiming to overcome the adverse influence of HSPs on the efficiency of photothermal treatment, various strategies have been developed in recent years. In this paper, inhibitory strategies for HSPs in PTT were classified according to the different principles, and the corresponding research progresses were introduced through study cases. The strategies mainly include the application of HSPs inhibitors in PTT system, blocking the glycolysis metabolism of tumor cells, inducing the production of lipid peroxide or highly reactive oxygen species (ROS), and HSPs gene interference and gene knockout. In addition, the advantages and limitations of the various strategies were compared and summarized. At the end, perspectives of HSP inhibition in photothermal therapy systems were discussed, and we proposed that joint strategies or designing new carriers and drugs would be promising to overcome the limitations of existing strategies.

Key words： photothermal therapy (PTT) heat shock proteins (HSPs) inhibition

Received: 01 April 2022

PACS:

R318

Corresponding Authors: ^*E-mail: went@ibms.pum.edu.cn

About author:: ^#Member, Chinese Society of Biomedical Engineering

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	Meng Yiling
	Wen Tao
	Xu Haiyan

Cite this article:

Meng Yiling,Wen Tao,Xu Haiyan. Research Progress on Inhibitory Strategies of Heat Shock Proteins in Photothermal Therapy[J]. Chinese Journal of Biomedical Engineering, 2023, 42(2): 229-234.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2023.02.011 OR http://cjbme.csbme.org/EN/Y2023/V42/I2/229

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