结合表型信息的阿尔兹海默症图卷积神经网络分类方法研究

doi:10.3969/j.issn.0258-8021.2021.02.07

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Abstract The early detection and diagnosis of Alzheimer's disease (AD) has important clinical and social significance. Because of the abnormal changes in the topological properties of the functional brain network in AD patients and the large differences in the prevalence of Alzheimer's in different phenotype types, this study combined brain network features and phenotypic information to construct training features for classification at different stages of Alzheimer's disease. In recent years, the graph convolutional neural network (GCN) classification method has proved to be the best choice for graph data learning tasks. Therefore, this paper applied GCN to the classification study of AD and completed for healthy control (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) and AD four types of classification. Herein we used the basic framework of population map convolutional neural network to classify 300 subjects in the ADNI database, and improved methods were proposed in terms of the similarity between the subjects in the population graph and the characteristics of the brain network of the subjects. In terms of the similarity between graph subjects, the construction of other phenotypic graph structures was performed using methods such as addition, improved initial value, only feature similarity, only phenotypic similarity, and four other combination methods; in terms of a brain network feature, combined with multi-modal thinking, the phenotypic information was converted into binary features, and the brain network features were spliced into total features. In addition, this study tried to use different types of phenotype information to the experiments. Finally, 10-fold cross-validation was used to verify the results. The results showed that the improvement in both aspects increased the accuracy to a certain extent. The classification accuracy was the best while using brain network similarity as the edge weight of graph construction, and the phenotypic information (age or gender) without dimension reduction as the characteristics of subjects (nodes). Compared with the original method, the accuracy was improved from 80% to 82%. It was shown that the brain network features and phenotype information were important features in the brain disease classification task, which can help to improve the accuracy of classification task, therefore is of research implications.

Key words： Alzheimer's disease brain network classification graph convolutional neural network phenotypic information

Received: 27 November 2019

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R318

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	Articles by authors
	Li Yuming
	He Xuan
	Zhu Hongbo
	Ge Zhuochen
	Zhou Longjie

Cite this article:

Li Yuming,He Xuan,Zhu Hongbo, et al. Study on Classification Method of Alzheimer's Disease Convolutional Neural Network Combined with Phenotypic Information[J]. Chinese Journal of Biomedical Engineering, 2021, 40(2): 177-187.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2021.02.07 OR http://cjbme.csbme.org/EN/Y2021/V40/I2/177

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