大鼠脑缺血不同时期躯体感觉诱发电位的研究

doi:10.3969/j.issn.0258-8021. 2014. 03.06

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Abstract The electroencephalogram (EEG) is often applied to diagnose the diseases of the nervous system because of its advantages of high time resolution, clear observation to the dynamic changes for the brain activity, and the completely noninvasive detection. To explore somatosensory evoked potential (SEP) changes and functional recovery of the cerebral cortex following cerebral ischemia, 25 Sprague Dawley male rats have been divided into 5 groups, which include control group and four ischemia groups， 4 h group, 24 h group, 48 h group and 1 w group. The rat model of cerebral ischemia has been established by middle cerebral artery occlusion (MCAO) in the left hemisphere. SEP of left cortex was detected by electrically stimulating the right median nerve of rat paw. The EEG in resting state was analyzed by spectral technology. The result shows that， after 4 hours of MCAO the latency of SEP has been significantly prolonged（（16.0±1.1）ms vs（33.7±1.3）ms，P<0.01）, and the amplitude is decreased（（197.2±13.0）μV vs（25.1±2.0）μV，P<0.01）. The energy of θ wave, α wave, β wave, γ wave are significantly smaller. θ wave:（139 367.86±178.66）μV² vs（2.22±0.40）μV²，P <0.01；α wave:（5 389.33±25.55）μV²vs（0.23±0.01）μV²，P <0.01；β wave:（7911±4.16）μV²vs（0.01±0.01）μV²，P<0.01；γ wave:（0.30±0.12）μV²vs（0.00±0.00）μV²，P <0.01. With the extension of time after operation, the difference of these characteristics between control group and ischemia group has been reduced gradually (P <0.01). However, these characteristics cannot reach the normal. This indicates that SEP can be used to evaluate the function of cerebral cortex in rats with cerebral ischemia in a certain extent.

Key words： cerebral ischemia; somatosensory evoked potential (SEP) power spectrum primary somatosensory cortex

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	ZHANG Yan¹HAO DongMei^1#*LV XiuHua¹WANG XiuLi² TIAN YunQing³

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ZHANG Yan¹HAO DongMei^1#*LV XiuHua¹WANG XiuLi² TIAN YunQing³
. Somatosensory Evoked Potential Changes in a Rat Model of Cerebral Ischemia[J]. journal1, 2014, 33(3): 297-305.

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http://cjbme.csbme.org/EN/ 10.3969/j.issn.0258-8021. 2014. 03.06 OR http://cjbme.csbme.org/EN/Y2014/V33/I3/297

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