Somatosensory Evoked Potential Changes in a Rat Model of Cerebral Ischemia
1 College of Life and BioEngineering, Beijing University of Technology, Beijing 100124, China
2 Institute of Health Science, Anhui University, Hefei 230601, China
3 State Intellectual Property Office of the P.R.C, Beijing 100088, China
Abstract The electroencephalogram (EEG) is often applied to diagnose the diseases of the nervous system because of its advantages of high time resolution, clear observation to the dynamic changes for the brain activity, and the completely noninvasive detection. To explore somatosensory evoked potential (SEP) changes and functional recovery of the cerebral cortex following cerebral ischemia, 25 Sprague Dawley male rats have been divided into 5 groups, which include control group and four ischemia groups， 4 h group, 24 h group, 48 h group and 1 w group. The rat model of cerebral ischemia has been established by middle cerebral artery occlusion (MCAO) in the left hemisphere. SEP of left cortex was detected by electrically stimulating the right median nerve of rat paw. The EEG in resting state was analyzed by spectral technology. The result shows that， after 4 hours of MCAO the latency of SEP has been significantly prolonged（（16.0±1.1）ms vs（33.7±1.3）ms，P<0.01）, and the amplitude is decreased（（197.2±13.0）μV vs（25.1±2.0）μV，P<0.01）. The energy of θ wave, α wave, β wave, γ wave are significantly smaller. θ wave:（139 367.86±178.66）μV2 vs（2.22±0.40）μV2，P <0.01；α wave:（5 389.33±25.55）μV2 vs（0.23±0.01）μV2，P <0.01；β wave:（7911±4.16）μV2 vs（0.01±0.01）μV2，P<0.01；γ wave:（0.30±0.12）μV2 vs（0.00±0.00）μV2，P <0.01. With the extension of time after operation, the difference of these characteristics between control group and ischemia group has been reduced gradually (P <0.01). However, these characteristics cannot reach the normal. This indicates that SEP can be used to evaluate the function of cerebral cortex in rats with cerebral ischemia in a certain extent.
ZHANG Yan1 HAO DongMei1#*LV XiuHua1 WANG XiuLi2 TIAN YunQing3 . Somatosensory Evoked Potential Changes in a Rat Model of Cerebral Ischemia[J]. journal1, 2014, 33(3): 297-305.
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