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| Fabrication of Organ-on-a-Chip by 3D Printing Technology |
| Liu Yan1,2, Yang Qingzhen1,2*, Chen Xiaoming3, Gu Fangwei1,2, Zhang Hui1,2 |
1(School of Life Science and Technology, Xi′an Jiaotong University, Xi’an 710049, China)
2(Bioinspired Engineering and Biomechanics Center, Xi′an Jiaotong University, Xi′an 710049, China)
3(State Key Laboratory for Manufacturing Systems Engineering, Xi′an Jiaotong University, Xi′an 710049, China) |
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Abstract Organ-on-a-chip is an emerging in vitro biological model with great prospects in biomedical researches. However, its development is often limited by the cumbersome and expensive fabrication process. Recently, researchers have adopted 3D printing technology into the fabrication and therefore made this process simpler and less expensive. Besides, this strategy also increased the complexity of chip structure and allowed the one-step fabrication. 3D printing technology has strongly promoted organ-on-a-chip related researches and contributed to its wide application. This paper reviewed the research status of 3D printing technology in the fabrication of organ-on-a-chip, including the development background of organ-on-a-chip, limitations of traditional fabrication methods, the technical classification and biomedical applications of 3D printing technology.Five 3D printing methods were listed based on different forming principles, and their characteristics and applications in chip fabrication were compared as well. Besides, the applications of 3D printing technology in the construction of liver, kidney, blood vessel, heart and other organs-on-chips were also discussed. Finally, we concluded with our thoughts on the challenges and future perspectives of this technology.
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Received: 17 March 2019
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