黑色素瘤术后水凝胶治疗平台的研究进展

doi:10.3969/j.issn.0258-8021.2025.05.012

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Abstract Melanoma has remarkably gained extensive attention owing to its high morbidity and mortality. Surgical resection is the mainstay for melanoma therapy in clinic. Inhibiting the recurrence of melanoma and healing after-surgical wounds have been great challenges in clinical studies. Hydrogels is a class of three-dimensional network of biomaterials with unique porous structures, and hydrogel therapy platforms can offer solutions to these challenges. In this review, we summarized recent developments of polymer-based hydrogels as therapy platforms for local delivery of therapeutic agents for postoperative melanoma therapy. According to the mechanisms that induce cancer cell death in melanoma, we focused on the latest research achievements of hydrogel chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT), immunotherapy, and combination therapies. Furthermore, the merits of postoperative therapy platform of the hydrogels were summarized and existing challenges and further perspectives of this platform for melanoma postoperative therapy were discussed.

Key words： melanoma hydrogel wound healing anti-tumor recurrence

Received: 09 February 2025

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R318

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	Li Jinhua
	Sun Honggang

Cite this article:

Li Jinhua,Sun Honggang. Research Progress on Melanoma Postoperative Hydrogel Therapy Platform[J]. Chinese Journal of Biomedical Engineering, 2025, 44(5): 622-630.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2025.05.012 OR http://cjbme.csbme.org/EN/Y2025/V44/I5/622

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