水凝胶粘合剂在心脏和血管修复领域的研究现状

doi:10.3969/j.issn.0258-8021.2025.02.011

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Abstract Hydrogels are highly biocompatible biomaterials composed of crosslinked three-dimensional networks of hydrophilic polymers, which can be structurally and functionally designed to modulate their physicochemical properties and thus have a wide range of biomedical application potential. Among them, hydrogels with adhesion ability are widely used as medical tissue adhesives in wound repair of skin, muscle, nerve, bone, cornea, organs and blood vessels due to their ability to mimic physiological environment, excellent biocompatibility, outstanding mechanical properties and most importantly - strong adhesion to tissues. In this paper, we introduced the current state of research on hydrogel adhesives, providing a comprehensive overview of their adhesion mechanisms to tissues, fundamental design principles, associated characteristics, and application contexts, with particular emphasis on their use in cardiac and vascular repair. Additionally, the limitations of existing hydrogel adhesive applications and anticipates future advancements were analyzed, aiming to offer a valuable reference for their clinical application in surgical settings.

Key words： hydrogel medical tissue adhesive heart vascular surgery

Received: 27 February 2024

PACS:

R318

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	Articles by authors
	Chen Shihan
	Fan Jiefu
	Lu Qingsheng

Cite this article:

Chen Shihan,Fan Jiefu,Lu Qingsheng. Current Research on Hydrogel Adhesives for Cardiac and Vascular Repair[J]. Chinese Journal of Biomedical Engineering, 2025, 44(2): 232-240.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2025.02.011 OR http://cjbme.csbme.org/EN/Y2025/V44/I2/232

[1] Gao Ning, Mann S. Membranized coacervate microdroplets: from versatile protocell models to cytomimetic materials [J]. Acc Chem Res, 2023, 56(3): 297-307.
[2] Rasmussen K, Willemsen PR, Ostgaard K. Barnacle settlement on hydrogels [J]. Biofouling, 2002, 18(3): 177-191.
[3] Katsuyama Y, Kurokawa T, Kaneko T, et al. Inhibitory effects of hydrogels on the adhesion, germination, and development of zoospores originating from Laminaria angustata [J]. Macromolecular Bioscience, 2002, 2(4): 163-169.
[4] Murosaki T, Noguchi T, Kakugo A, et al. Antifouling activity of synthetic polymer gels against cyprids of the barnacle (Balanus amphitrite) in vitro [J]. Biofouling, 2009, 25(4): 313-320.
[5] Pinelli F, Magagnin L, Rossi F. Progress in hydrogels for sensing applications: a review [J]. Materials Today Chemistry, 2020, 17: 100317.
[6] Jung IY, Kim JS, Choi BR, et al. Hydrogel based biosensors for in vitro diagnostics of biochemicals, proteins, and genes [J]. Adv Healthc Mater, 2017, 6(12): 1601475.
[7] Barhoum A, Sadak O, Ramirez IA, et al. Stimuli-bioresponsive hydrogels as new generation materials for implantable, wearable, and disposable biosensors for medical diagnostics: principles, opportunities, and challenges [J]. Advances in Colloid and Interface Science, 2023, 317: 102920.
[8] Corrie L, Gulati M, Awasthi A, et al. Harnessing the dual role of polysaccharides in treating gastrointestinal diseases: as therapeutics and polymers for drug delivery [J]. Chemico-Biological Interactions, 2022, 368: 110238.
[9] Pushpamalar J, Meganathan P, Tan Huili, et al. Development of a polysaccharide-based hydrogel drug delivery system (DDS): an update [J]. Gels, 2021, 7(4): 153.
[10] Xing Ruirui, Li Shukun, Zhang Ning, et al. Self-assembled injectable peptide hydrogels capable of triggering antitumor immune response [J]. Biomacromolecules, 2017, 18(11): 3514-3523.
[11] Wang Li, Ding Xiaoya, Fan Lu, et al. Self-healing dynamic hydrogel microparticles with structural color for wound management [J]. Nanomicro Lett, 2024, 16(1): 232.
[12] Wang Yu, Guo Jiahui, Cao Xinyue, et al. Developing conductive hydrogels for biomedical applications [J]. Smart Med, 2024, 3(1): e20230023.
[13] Kim S, Nowicki KW, Gross BA, et al. Injectable hydrogels for vascular embolization and cell delivery: the potential for advances in cerebral aneurysm treatment [J]. Biomaterials, 2021, 277: 121109.
[14] Yang Jiahao, Wang Shige. Polysaccharide-Based multifunctional hydrogel bio-adhesives for wound healing: a review [J]. Gels, 2023, 9(2): 138.
[15] Bovooneb G, Dudaryeva OY, Macro-Dufort B, et al. Engineering hydrogel adhesion for biomedical applications via chemical design of the junction [J]. ACS Biomater Sci Eng, 2021, 7(9): 4048-4076.
[16] Yang Jiawei, Bai Ruobing, Chen Baohong, et al. Hydrogel adhesion: a supramolecular synergy of chemistry, topology, and mechanics [J]. Advanced Functional Materials, 2020, 30(2): 1901693.
[17] Hu Xiaobo, Vatankhan-Varnoosfaderani M, Zhou Jing, et al. Weak hydrogen bonding enables hard, strong, tough, and elastic hydrogels [J]. Adv Mater, 2015, 27(43): 6899-6905.
[18] Smart JD. The basics and underlying mechanisms of mucoadhesion [J]. Adv Drug Deliv Rev, 2005, 57: 1556-1568.
[19] Hofman AH, van Hees IA, Yang Juan, et al. Bioinspired underwater adhesives by using the supramolecular toolbox [J]. Adv Mater, 2018, 30(19): e1704640.
[20] Roy CK, Guo Honglei, Sun Taolin, et al. Self-adjustable adhesion of polyampholyte hydrogels [J]. Adv Mater, 2015, 27(45): 7344-7348.
[21] Heinzmann C, Weder C, de Espinosa LM. Supramolecular polymer adhesives: advanced materials inspired by nature [J]. Chem Soc Rev, 2016, 45(2): 342-358.
[22] Yang Jiawei, Bai Ruobing, Suo Zhigang. Topological adhesion of wet materials [J]. Adv Mater, 2018, 30(25): e1800671.
[23] Li Jianyu, Celiz AD, Yang Jiawei, et al. Tough adhesives for diverse wet surfaces [J]. Science, 2017, 357: 378-381.
[24] Yuk H, Zhang Teng, Lin Shaoting, et al. Tough bonding of hydrogels to diverse non-porous surfaces [J]. Nat Mater, 2016, 15(2): 190-196.
[25] Yi Yating, Xie Chaoming, Liu Jin, et al. Self-adhesive hydrogels for tissue engineering [J]. J Mater Chem B, 2021, 9(42): 8739-8767.
[26] 郭竣畅. 生物粘附粉末水凝胶的制备及其应用研究[D]. 成都:电子科技大学, 2022.
[27] Zhao Xin, Guo Baolin, Wu Hao, et al. Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing [J]. Nat Commun, 2018, 9(1): 2784.
[28] Benoit DS, Durney AR, Anseth KS. Manipulations in hydrogel degradation behavior enhance osteoblast function and mineralized tissue formation [J]. Tissue Eng, 2006, 12(6): 1663-1673.
[29] Muir VG, Burdick JA. Chemically modified biopolymers for the formation of biomedical hydrogels [J]. Chem Rev, 2021, 121(18): 10908-10949.
[30] Collins MN, Birkinshaw C. Hyaluronic acid based scaffolds for tissue engineering - a review [J]. Carbohydr Polym, 2013, 92(2): 1262-1279.
[31] Slaughter BV, Khurshid SS, Fisher OZ, et al. Hydrogels in regenerative medicine [J]. Adv Mater, 2009, 21(32-33): 3307-3329.
[32] Tokatlian T, Cam C, Siegman SN, et al. Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs [J]. Acta Biomater, 2012, 8(11): 3921-3931.
[33] Annabi N, Nichol JW, Zhong Xia, et al. Controlling the porosity and microarchitecture of hydrogels for tissue engineering [J]. Tissue Eng Part B Rev, 2010, 16(4): 371-383.
[34] Huebsch N, Lippens E, Lee K, et al. Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation [J]. Nat Mater, 2015, 14(12): 1269-1277.
[35] Cui Chunyan, Wu Tengling, Chen Xinyu, et al. A janus hydrogel wet adhesive for internal tissue repair and anti-postoperative adhesion [J]. Advanced Functional Materials, 2020, 30(49): 2005689.
[36] Rao Ping, Sun Taolin, Chen Liang, et al. Tough hydrogels with fast, strong, and reversible underwater adhesion based on a multiscale design [J]. Adv Mater, 2018, 30(32): e1801884.
[37] 许雨芩,杨建军,吴庆云,等. 抗菌型高分子水凝胶研究进展 [J].化工新型材料, 2022, 50(9): 218-224, 228.
[38] Guo Shen, Ren Yikun, Chang Rong, et al. Injectable self-healing adhesive chitosan hydrogel with antioxidative, antibacterial, and hemostatic activities for rapid hemostasis and skin wound healing [J]. ACS Appl Mater Interfaces, 2022,14(30): 34455-34469.
[39] Ahluwalia V, Elumalai S, Kumark V, et al. Nano silver particle synthesis using Swertia paniculata herbal extract and its antimicrobial activity [J]. Microb Pathog, 2018, 114: 402-408.
[40] Sahu I, Vermav J, Bera AK, et al. Synergistic coassembly of folic acid-based supramolecular polymer with a covalent polymer toward fabricating functional antibacterial biomaterials [J]. ACS Appl Mater Interfaces, 2024, 16(26): 34141-34155.
[41] Liang Yuqing, Xu Huiru, Li Zhenlong, et al. Bioinspired injectable self-healing hydrogel sealant with fault-tolerant and repeated thermo-responsive adhesion for sutureless post-wound-closure and wound healing [J]. Nanomicro Lett, 2022, 14: 185.
[42] Wang Jinghui, Liu Xiaoyu, Wang Yanqin, et al. Casein micelles embedded composite organohydrogel as potential wound dressing [J]. Int J Biol Macromol, 2022, 211: 678-688.
[43] Yao Shasha, Zhao Yueqi, Xu Yifei, et al. Injectable dual-dynamic-bond cross-linked hydrogel for highly efficient infected diabetic wound healing [J]. Adv Healthc Mater, 2022, 11(14): e2200516.
[44] Liu Yuqing, Li Yinghao, Shang Haitao, et al. Underwater instant adhesion mechanism of self-assembled amphiphilic hemostatic granular hydrogel from Andrias davidianus skin secretion [J]. iScience, 2022, 25(10): 105106.
[45] Chen Xinyu, Cui Chunyan, Liu Yang, et al. A robust poly(N-acryloyl-2-glycine)-based sponge for rapid hemostasis [J]. Biomater Sci, 2020, 8(13): 3760-3771.
[46] Wang Shuguang, Wang Feng, Shi Kun, et al. Osteichthyes skin-inspired tough and sticky composite hydrogels for dynamic adhesive dressings [J]. Composites Part B-Engineering, 2022, 241: 110010.
[47] Guo Shen, Yao Minghao, Zhang Dan, et al. One-step synthesis of multifunctional chitosan hydrogel for full-thickness wound closure and healing [J]. Adv Healthc Mater, 2022, 11(4): e2101808.
[48] Bannerman D, Pascual-Gil S, Radisic M. An optimal gel patch for the injured heart [J]. Nat Biomed Eng, 2019, 3: 592-593.
[49] Pomeroy JE, Helfer A, Bursac N. Biomaterializing the promise of cardiac tissue engineering [J]. Biotechnol Adv, 2020, 42: 107353.
[50] Liang Shuang, Zhang Yinyu, Wang Hongbo, et al. Paintable and rapidly bondable conductive hydrogels as therapeutic cardiac patches [J]. Adv Mater, 2018, 30(23): e1704235.
[51] Liang Wei, Chen Jingrui, Li Lingyan, et al. Conductive hydrogen sulfide-releasing hydrogel encapsulating ADSCs for myocardial infarction treatment [J]. ACS Appl Mater Interfaces, 2019, 11(16): 14619-14629.
[52] Lin Xiao, Liu Yue, Bai Aobing, et al. A viscoelastic adhesive epicardial patch for treating myocardial infarction [J]. Nat Biomed Eng, 2019, 3(8): 632-643.
[53] Pourshahrestanip S, Zeimaran E, Kadrik NA, et al. Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing [J]. Adv Healthc Mater, 2020, 9(20): e2000905.
[54] Hong Yi, Zhou Feifei, Hua Yujie, et al. A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds [J]. Nat Commun, 2019, 10(1): 2060.
[55] Ryu JH, Lee Y, Kong WH, et al. Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials [J]. Biomacromolecules, 2011, 12(7): 2653-2659.
[56] An S, Jeon EJ, Jeon J, et al. A serotonin-modified hyaluronic acid hydrogel for multifunctional hemostatic adhesives inspired by a platelet coagulation mediator [J]. Mater Horizons, 2019, 6: 1169-1178.
[57] Narkar AR, Barker B, Clisch M, et al. pH responsive and oxidation resistant wet adhesive based on reversible catechol-boronate complexation [J]. Chem Mater, 2016, 28(15): 5432-5439.
[58] Lu Yapeng, Zhao Meihui, Peng Ye, et al. A physicochemical double-cross-linked gelatin hydrogel with enhanced antibacterial and anti-inflammatory capabilities for improving wound healing [J]. J Nanobiotechnology, 2022, 20(1): 426.
[59] Zhang Wanglong, Zhang Yiwei, Dai Yu, et al. Gradient adhesion modification of polyacrylamide/alginate-calcium tough hydrogels [J]. J Mater Chem B, 2022, 10(5): 757-764.