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| Mitotic Detection in Breast Histopathology Images Using Local and Regional Hierarchical Information |
| Cai Yu, Tang Qiling*, Liu Ziyi |
| (School of Biomedical Engineering, South-Central Minzu University, Wuhan 430074, China) |
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Abstract Statistically counting the number of mitotic cells in histological images of breast tumor tissue is an important diagnostic basis for the grading and prognosis of breast cancer. Currently, the counting tasks are performed manually by pathologists, which is a time-consuming and laborious task. To address this challenge, this paper proposed a method for mitotic detection in breast cancer pathology images from local to regional stratification. The framework as a whole consisted of two stages. The first stage was a cell localization network, which was responsible for screening and locating candidate mitotic cell blocks from whole section images while introducing a deep supervision mechanism with decoupled detection heads to enhance performance. The second stage was the mitotic cell validation network, which was responsible for further refining the classification of a large number of candidate cell image blocks by using a contextual fusion network based on a graph-attention mechanism to modulate the original response of local central blocks by integrating a large range of regional features to obtain more accurate classification results. We achieved F-Scores of 0.676, 0.809, and 0.797 on the ICPR MITOSIS 2014, ICPR MITOSIS 2012, and TUPAC16 datasets, respectively, using 960, 35, and 649 HPF as training sets, and 240, 15, and 7 HPF as test sets, respectively, where the recall rates all achieved optimal results of 0.878, 0.858 and 0.875, respectively. The results indicated that the proposed automatic detection method efficiently detected the cancer cells in the pathological sections, showing significant clinical application value.
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Received: 16 October 2022
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Corresponding Authors:
*E-mail: qltang@mail.scuec.edu.cn
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