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| Polycaprolactone-Based Composite Scaffolds in Bone Tissue Engineering: Research Status and Prospect |
| Yang Xiangjun1, Chen Junyu1,2, Zhu Zhou1,2, Wan Qianbing1,2* |
1(West China School of Stomatology, Sichuan University, Chengdu 610041, China)
2(West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) |
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Abstract Three-dimensional scaffolds have received considerable attention in the field of bone tissue engineering. Polycaprolactone (PCL) is widely used in the preparation of 3D scaffolds due to its good biocompatibility. However, pure PCL scaffolds have poor hydrophilicity and low biological activity, which limit their application in biomedical field. With the development of bone tissue engineering, a large number of investigations combined PCL with various inorganic substances, metal elements or natural collagen to improve the properties or introduce new properties into the PCL scaffolds. Based on the domestic and foreign literature, in this paper, the selection of materials for PCL bone tissue engineering composite scaffolds was summarized, including inorganic materials, hydrogel materials, metal elements, small molecule drugs and bioactive molecules. The properties and osteogenic effects of the various composite scaffolds were reviewed from five aspects, aiming to provide insights for the research and clinical application of PCL in the bone tissue engineering.
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Received: 10 August 2020
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