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Chinese Journal of Biomedical Engineering  2019, Vol. 38 Issue (1): 9-17    DOI: 10.3969/j.issn.0258-8021.2019.01.002
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Optic Disc Localization Based on Regional Proposal Strategy
Tang Yiping*, Wang Liran, He Xia, Chen Peng, Yuan Gongping
School of Information Engineering, Zhejiang University of Technology, Hangzhou 310023, China
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Abstract  The localization of optic disc (OD) is very important for computer-aided diagnosis of the ophthalmology diseases with fundus images. In this paper, a method of OD localization based on regional proposal strategy was proposed. First, the fundus image was mapped from the pixel domain to the feature domain, and candidate regions of OD were generated by using the regional proposal strategy in the obtained feature maps. Next, the candidate regions were sampled according to the certain criteria, and a fully connected layer was constructed to perform deep feature extraction. The location refinement of the candidate region was achieved by using the constraint of the loss function. At last, OD visibility was judged by filtering of the confidence threshold. If the OD was visible, the center of the candidate region with the highest degree of confidence was regarded as OD coordinate of the fundus image. The correct position of OD was obtained. Experiments were conducted in three public fundus image databases (DRIVE (40 images), MESSIDOR (1200 images) and STARE (400 images)). Testing results were 100%, 99.9% and 98.8%. Experimental results showed that the proposed method could reach the OD localization fast, accurately and robust, which was superior to existing OD localization methods. The pre-judgment of OD visibility was more consistent with the requirements of practical application. The proposed method was expected to contribute to the diagnosis of fundus diseases.
Key wordsoptic disc localization      region proposal strategy      fundus images      deep learning      convolutional neural network     
Received: 08 December 2017     
PACS:  R318  
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Articles by authors
Tang Yiping
Wang Liran
He Xia
Chen Peng
Yuan Gongping
Cite this article:   
Tang Yiping,Wang Liran,He Xia, et al. Optic Disc Localization Based on Regional Proposal Strategy[J]. Chinese Journal of Biomedical Engineering, 2019, 38(1): 9-17.
URL:  
http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2019.01.002     OR     http://cjbme.csbme.org/EN/Y2019/V38/I1/9
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