生物组织电特性在体测量微创电极的设计及应用研究

doi:10.3969/j.issn.0258-8021.2018.05.008

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Abstract According to the principle of parallel plate capacitance method, the charge distribution of the electrode was calculated by the method of moment and a minimally invasive probe electrode was designed for in vivo measurement in this study. The volume of tissue gripped by the probe was only 0.8 mm³. The electric field distribution in the miniature electrode was simulated by the finite element method. It was proved that the minimally invasive electrode can effectively shield the edge effect. Nude mice were divided into 3 groups according to the time of tumor inoculation (7, 14, 21 d), 10 mice in each group. Within the frequency range of 0.5-5 MHz, the electrical impedance and impedance angles of the tumor tissue and normal tissue of mice were measured in vivo and in vitro, and the corresponding electrical properties (conductivity and permittivity) were calculated. The electrical properties of tumor tissue, muscle tissue and adipose tissue were measured in vivo at 1, 3 and 5 MHz. The results showed that the conductivity and permittivity of tumor in vivo increased with the tumor growth in the frequency range of 0.5-5 MHz. There are significant differences in electrical properties between in vivo and in vitro tumor. At the three frequencies measured, there are significant differences in electrical properties between tumor tissue, muscle tissue and adipose tissue. The designed minimally invasive electrode achieves the purpose of minimally invasive in vivo measurement.

Key words： electrical properties micro-invasive electrode tumor tissue in vivo measure

Received: 05 April 2018

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R318

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	Articles by authors
	Zhang Yan
	Cao Shuang
	Zhang Shunqi
	Ma Ren
	Yin Tao
	Liu Zhipeng

Cite this article:

Zhang Yan,Cao Shuang,Zhang Shunqi, et al. Study on Micro-Invasive Electrode Applied to Bio-Tissue’s Electrical Properties Measuring In-Vivo[J]. Chinese Journal of Biomedical Engineering, 2018, 37(5): 568-575.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2018.05.008 OR http://cjbme.csbme.org/EN/Y2018/V37/I5/568

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