人体正常与肿瘤甲状腺组织10 Hz~100 MHz间介电特性的对比研究

doi:10.3969/j.issn.0258-8021.2018.06.007

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Abstract The aim of this study was to investigate the dielectric properties of normal and tumor tissues of human thyroid, make clear the difference between the dielectric parameters of those tissues, and to provide a basis for the rapid identification of pathological thyroid tissues based on dielectric properties. The dielectric properties of 135 thyroid tissues were measured ex vivo at frequency range of 10 Hz to 100 MHz using the standardized measurement platform. Then the samples were classified according to the pathological results, and the differences in dielectric properties of each group were found after statistical analysis. The samples can be divided into three groups: normal (95 cases), malignant tumor (19 cases) and benign tumor (21 cases). All of these samples have shown an increase in conductivity with increasing frequency, and 2 main frequency dispersion regions of α and β were also observed at the frequency range of 10 Hz~100 MHz. Through the modeling analysis, the characteristic parameters of the dielectric properties, ρ_∞(Ω·cm), ρ₀(Ω·cm), f_cα(kHz), δ_α, f_cβ(MHz) and δ_β, were investigated. Normal thyroid tissue was 54.8±27.5, 385.6±3.3, 40.3±10.9, 0.61±0.04, 97.7±1.7 and 0.48±0.05, respectively. Benign tumor tissue was 118.3±8.5, 418.1±84.5, 26.3±13.1, 0.62±0.04, 3.5±0.8 and 0.56±0.06, respectively. Malignant tumor tissue was 67.7±5.1, 592.9±73.3, 10.2±2.6, 0.66±0.06, 6.37±4.1 and 0.36±0.07, respectively. Statistical analysis results indicated that the dielectric properties of normal thyroid tissue significantly different from that of malignant tumor tissue in parameters of ρ₀, f_cα,f_cβand δ_β, which was also significantly different from that of benign tumor tissue in parameters of ρ_∞, f_cα and δ_β. The significant difference was also detected in parameters of ρ_∞, ρ₀, f_cα, f_cβ and δ_β between malignant and benign thyroid tumor tissues. The dielectric properties of the tissue could reflect the changes in the microstructure to a certain extent. These findings provided evidence that there is a certain correlation between the dielectric properties and the nature as well as microstructure of the different types of thyroid tissues, as well as data supporting rapid differentiation and identification of pathological thyroid tissues.

Key words： thyroid living tissue dielectric properties

Received: 22 February 2018

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R318

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	Articles by authors
	Shi Xuetao
	ZhouYimin
	Ji Zhenyu
	Cai Zhanxiu
	You Fusheng
	Fu Feng
	Dong Xiuzhen

Cite this article:

Shi Xuetao,ZhouYimin,Ji Zhenyu, et al. A Comparative Study on Dielectric Properties of Human Thyroid Normal and Tumor Tissues from 10 Hz to 100 MHz[J]. Chinese Journal of Biomedical Engineering, 2018, 37(6): 688-693.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2018.06.007 OR http://cjbme.csbme.org/EN/Y2018/V37/I6/688

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