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| The Effect of Different Curvature on the Distribution of Nitric Oxide Concentration in the Curved Arterial Segment |
| Zhao Hongjun1, Han Jintao2, Liu Cong1, Dov Jaron3, Qiao Huiting1#* |
1 (School of Biomedical Engineering, Beihang University, Beijing 100191, China)
2(Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital, Beijing 100191,China)
3(School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA) |
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Abstract Nitric oxide (NO) produced by the endothelium plays an important role in regulating vascular tone. However, the effect of different curvature on the distribution of NO concentration in the curved arterial segment has not been clear. We developed eleven mass transport models with different curvature to simulate the distributions for NO in blood, vascular walls and surrounding tissue. Results showed that the radical distribution of NO was uneven in the curved segment. The outer concentration was higher than the inner one. And the concentration difference increased and then decreased with the increased curvature. In the smooth muscle region, the concentration difference reached the maximum when the curved height was increased to 2mm under the condition of the vessel projection length was a constant (20 mm),where the curvature was increased to 0.04,the outer boundary concentration was 23.74% higher than the inner one. This study revealed the effect of different curvature on NO concentration, and suggested that the uneven distribution of NO might cause vascular morphology changes and lead to vascular disease. Those models may provide a theoretical support for the further research and vascular disease risk assessment.
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Received: 07 June 2016
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