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| Review of Normal Tissues Complication Probability Models |
1 Department of Radiotherapy, Shandong Tumor Hospital & Institute, Jinan 250117, China
2 Key Laboratory of Radiation Oncology of Shandong Province, Jinan 250117, China
3 Laboratory of Image Science and Technology, Southeast University, Nanjing 210096, China
4 Laboratoire Traitement du Signal et de l’Image (INSERMU1099), Universitéde Rennes 1, Rennes 35510, France |
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Abstract To predict the probability of radiotherapy complications, optimize radiotherapy plans and reveal the radiobiological characteristics by normal tissue complication probability (NTCP) models are becoming important issues in the radiation oncology field recently. All of them can be achieved by identifying the NTCP model parameters with clinical and followup data. In this work, six NTCP models from literatures, model identification and comparison methods were summarized; three improved NTCP models and some other complication predictive methods were introduced as well. Issues of NTCP in individual radiotherapy were discussed and proposed from the clinical application point of view.
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