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| Research Advances in the Tumor Ablation Induced by Nanosecond Pulse |
| Key Laboratory of MultiOrgan Combined Transplantation, Ministry of Public Health, the First Affiliated Hospital，School of Medicine, Zhejiang University, Hangzhou 310003, China |
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Abstract Cancer remains a leading cause of human death worldwide and the total number of cases globally is increasing constantly, thus it is urgent to explore new and effective therapies for the cancer treatment. This paper reviewed 10 primary biological hallmarks of the cancer, introduced the distinguished advantages of tumor ablation induced by nanosecond pulse targeting tumor biological hallmarks, such as inducing cell apoptosis, inhibiting angiogenesis, destroying tumor microenvironment. We also elaborated the research progress of tumor ablation induced by nanosecond pulse employed in the treatment of cutaneous melanoma, basal cell carcinoma, squamous cell carcinoma, hepatocellular carcinoma and other tumors, showing an attractive application prospect.
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［1］Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008［J］. Int J Cancer, 2010,127(12): 2893-2917.
［2］Jemal A, Bray F, Center MM, et al. Global cancer statistics［J］. CA Cancer J Clin, 2011,61(2): 69-90.
［3］Sener SF, Fremgen A, Menck HR, et al. Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database［J］. J Am Coll Surg, 1999,189(1): 1-7.
［4］Meulenbeld HJ, Bleuse JP, Vinci EM, et al. Randomized phase II study of danusertib in patients with metastatic castrationresistant prostate cancer after docetaxel failure［J］. BJU Int, 2013,111（1）：44-52.
［5］Jiang Wei, Chen Xiaoke, Xi Junjie, et al. Selective mediastinal lymphadenectomy without intraoperative frozen section examinations for clinical stage I nonsmallcell lung cancer: Retrospective study of 403 cases［J］. World J Surg, 2013, 37(2):392-397.
［6］Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010［J］. CA Cancer J Clin, 2010,60(5): 277-300.
［7］Davis JL, Pandalai P, Ripley RT, et al. Regional chemotherapy in locally advanced pancreatic cancer: RECLAP trial［J］. Trials, 2011,12：129.
［8］Hanahan D, Weinberg RA. The hallmarks of cancer［J］. Cell, 2000,100(1): 57-70.
［9］Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation［J］. Cell, 2011,144(5): 646-674.
［10］Satkauskas S, Batiuskaite D, SalomskaiteDavalgiene S, et al. Effectiveness of tumor electrochemotherapy as a function of electric pulse strength and duration［J］. Bioelectrochemistry, 2005,65(2): 105-111.
［11］Henshaw J, Mossop B, Yuan F. Relaxin treatment of solid tumors: effects on electric fieldmediated gene delivery［J］. Mol Cancer Ther, 2008,7(8): 2566-2573.
［12］Rey JI, Jaroszeski MJ, Gilbert RA. Feasibility study for focusing electric fields to mediate in vitro drug and gene delivery［J］. Conf Proc IEEE Eng Med Biol Soc, 2006,1: 5617-5620.
［13］White JA, Pliquett U, Blackmore PF, et al. Plasma membrane charging of Jurkat cells by nanosecond pulsed electric fields［J］. Eur Biophys J, 2011,40(8): 947-957.
［14］Kolb JF, Kono S, Schoenbach KH. Nanosecond pulsed electric field generators for the study of subcellular effects［J］. Bioelectromagnetics, 2006,27(3): 172-187.
［15］Schoenbach KH, Joshi R, Kolb J, et al. Subcellular effects of nanosecond electrical pulses［J］. Conf Proc IEEE Eng Med Biol Soc, 2004,7: 5447-5450.
［16］Chen Xinhua, Kolb JF, Swanson RJ, et al. Apoptosis initiation and angiogenesis inhibition: melanoma targets for nanosecond pulsed electric fields［J］. Pigment Cell Melanoma Res, 2010,23(4): 554-563.
［17］Beebe SJ, Fox PM, Rec LJ, et al. Nanosecond, highintensity pulsed electric fields induce apoptosis in human cells［J］. FASEB J, 2003,17(11): 1493-1495.
［18］Nuccitelli R, Pliquett U, Chen Xinhua, et al. Nanosecond pulsed electric fields cause melanomas to selfdestruct［J］. Biochem Biophys Res Commun, 2006,343(2): 351-360.
［19］Nuccitelli R, Tran K, Sheikh S, et al. Optimized nanosecond pulsed electric field therapy can cause murine malignant melanomas to selfdestruct with a single treatment［J］. Int J Cancer, 2010,127(7): 1727-1736.
［20］Nuccitelli R, Tran K, Athos B, et al. Nanoelectroablation therapy for murine basal cell carcinoma［J］. Biochem Biophys Res Commun, 2012,424(3): 446-450.
［21］Yang W, Wu YH, Yin D, et al. Differential sensitivities of malignant and normal skin cells to nanosecond pulsed electric fields［J］. Technol Cancer Res Treat, 2011,10(3): 281-286.
［22］Yin Dong, Yang Wangrong, Weissberg J, et al. Cutaneous papilloma and squamous cell carcinoma therapy utilizing nanosecond pulsed electric fields (nsPEF)［J］. PLoS One, 2012,[STHZ]7[STBZ](8): e43891.
［23］El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis［J］. Gastroenterology, 2007,132(7): 2557-2576.
［24］Beebe SJ, Chen Xinhua, Liu JA, et al. Nanosecond pulsed electric field ablation of hepatocellular carcinoma［J］. Conf Proc IEEE Eng Med Biol Soc, 2011,2011：6861-6865.
［25］Chen Xinhua, Zhuang Jie, Kolb JF, et al. Long term survival of mice with hepatocellular carcinoma after pulse power ablation with nanosecond pulsed electric fields［J］. Technol Cancer Res Treat, 2012,11(1): 83-93.
［26］Hall EH, Schoenbach KH, Beebe SJ. Nanosecond pulsed electric fields (nsPEF) induce direct electric field effects and biological effects on human colon carcinoma cells［J］. DNA Cell Biol, 2005,24(5): 283-291.
［27］Hall EH, Schoenbach KH, Beebe SJ. Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells［J］. Apoptosis, 2007,12(9): 1721-1731.
［28］Hall EH, Schoenbach KH, Beebe SJ. Nanosecond pulsed electric fields have differential effects on cells in the Sphase［J］. DNA Cell Biol, 2007,26(3): 160-171.
［29］Yao Chengguo, Mi Yan, Hu Xiaoqian, et al. Experiment and mechanism research of SKOV3 cancer cell apoptosis induced by nanosecond pulsed electric field［C］//Proceedings of the Annual International Conference of IEEEEMBS. Vancouver: IEEE, 2008: 1044-1047.
［30］Wang Jing, Guo Jinsong, Wu Shan, et al. Synergistic effects of nanosecond pulsed electric fields combined with low concentration of gemcitabine on human oral squamous cell carcinoma in vitro［J］. PLoS One, 2012,7(8): e43213.
［31］Stacey M, Osgood C, Kalluri BS, et al. Nanosecond pulse electrical fields used in conjunction with multiwall carbon nanotubes as a potential tumor treatment［J］. Biomed Mater, 2011,6(1): 011002.
［32］Beebe SJ, White J, Blackmore PF, et al. Diverse effects of nanosecond pulsed electric fields on cells and tissues［J］. DNA Cell Biol, 2003,22(12): 785-796.
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