磷脂酰聚乙二醇单甲醚的合成及其自组装纳米胶束的研究

doi:10.3969/j.issn.0258-8021.2012.06.016

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Abstract A series of phosphatidyl polyethyleneglycol monomethyl ether nanomicelles were synthesized by benzyl protecting, hydrogenation reduction and esterification using glycerol as raw material. The micelles were prepared by solvent evaporation method, and characterized and analized by fluorescent probe, scanning electron microscopy, transmission electron microscopy, Zeta PALSsubmicron size and potential analyzer. Experimental results showed that the mPEG-lipids formed spherical micelles with coreshell structure and an average diameter of 100～200 nm, and the CMC of nano-micelles were 10^-6mol/L. Compared to conventional small molecules surfactant, mPEGlipids micelles have better stability in water due to the lower CMC. Ambient effect such as salt, glucose exerts a strong influence on the stability of the micelles. And these influence is tightly correlated to their concentration. Due to their stable structure, phosphatidyl polyethyleneglycol monomethyl ether nano-micelles have promise of being applied as nano carriers for drugs.

Key words： amphiphilic copolymer phosphatidyl polyethyleneglycol monomethyl ether polymer micelle

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	WU Li CHEN Jing LIU TianJun^*

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WU Li CHEN Jing LIU TianJun^*. Synthesis and Self-Assembling NanoMicelles of Phosphatidyl Polyethyleneglycol Monomethyl Ether[J]. journal1, 2012, 31(6): 910-917.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2012.06.016 OR http://cjbme.csbme.org/EN/Y2012/V31/I6/910

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