新型醛基化海藻酸钠抗凝血涂层物制备及性能评价

doi:10.3969/j.issn.0258-8021.2012.06.017

Abstract
Figure/Table
References (0)
Related Citation (7)

Download: PDF (590 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract This study is aimed to use oxidated sodium alginate（OSA）to coat medical polyvinyl chloride (PVC) pipe used for extracorporeal circulation, and evaluate the hemocompatibility and biocompatibility. The PVC pipe was coated with OSA. Its hemocompatibility and biocompatibility were evaluated and compared with those of PVCC and heparin-coated PVCM. The anticoagulant properties of oxidated sodium alginate coating group（PVCS）was lower than PVCM（P＜0.05）, but significantly better than that of PVCC（P＜0.05）. The protein adhesion of PVCS was significantly lower than that of the PVCC（P＜0.05) and PVCM（P＜0.05）. The platelet adhesion of PVCS was significantly lower than that of PVCC（P＜0.05），but had no significantly difference from that of PVCM（P>0.05）. The expulsion rates of PVCS had a similar tendency to that of PVCM in 72 hours. CONCLUSION: The PVCS coating improved biocompatibility, anticoagulant property and stability of PVC.

Key words： aldehyde sodium alginate PVC pipe extracorporeal circulation anticoagulant properties biocompatibility

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Jin You^1LI Tong^2*GAO Wen Qing²YU Mei Li³HU Xiao Ming²XU Jin² LU HaiBin¹

Cite this article:

LI Jin You^1LI Tong^2*GAO Wen Qing²YU Mei Li³HU Xiao Ming²XU Jin² LU HaiBin¹. Preparation and Evaluation of Novel Anticoagulant Coating Material with Aldehyde Alginate[J]. journal1, 2012, 31(6): 918-924.

URL:

http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2012.06.017 OR http://cjbme.csbme.org/EN/Y2012/V31/I6/918

［1］Tagarakis GI,Tsilimingas NB. Heparincoated extracorporeal circulation systems in heart surgery ［J］. Recent Pat Cardiovasc Drug Discov,2009,4(3):177-179.
［2］Nozohoor S, Johnsson P, Scicluna S, et al. A casecontrolled evaluation of the Medtronic Resting Heart System compared with conventional cardiopulmonary bypass in patients undergoing isolated coronary artery bypass surgery ［J］. Interact Cardiovasc Thorac Surg, 2012,14(5):599-604.
［3］Ovrum E, Tangen G, Tllfsrud S, et al. Heparinized cardiopulmonary bypass circuits and low systemic anticoagulation: an analysis of nearly 6000 patients undergoing coronary artery bypass grafting ［J］. Thorac Cardiovasc Surg, 2011,141(5):1145-1149.
［4］Nilsson UR, Larm O, Nilsson B, et al. Modification of the complement binding properties of polystyrene: effects of endpoint heparinattachment. Scand J Immunol ［J］. 1993,37(3):349-354.
［5］Nishino T, Yokoyama G, Dobashi K, et al. Isolation, purification, and characterization of fucosecontaining sulfated polysaccharides from the brown seaweed Ecklonia kurome and their bloodanticoagulant activities ［J］. Carbohydr Res, 1989,186(1):119-148.
［6］Bron JL, Vonk LA, Smit TH, et al. Engineering alginate for intervertebral disc repair ［J］. Mech Behav Biomed Mater 2011,4(7):1196-1205. 
［7］Popa EG, Gomes ME, Reis RL. Cell delivery systems using alginate—carrageenan hydrogel beads and fibers for regenerative medicine applications ［J］. Biomacromolecules, 2011,12(11):3952-3961. 
［8］Bouhadir KH, Lee KY, Alsberg E, et al. Degradation of partially oxidized alginate and its potential application for tissue engineering ［J］. Biotechnol Prog, 2001,〖STHZ〗17(5):945-995.
［9］何淑兰、张敏、耿占杰,等, 部分氧化海藻酸钠的制备与性能［J］.应用化学,2005,22（9）:1007-1011.
［10］钟方晓、任海华、李岩.多糖含量测定方法比较［J］.时珍国医国药2007,3（8）:1916-1917.
［11］Valdes TI, Ciridon W, Ratner BD, et al. Surface modification of a perfluorinated ionomer using a glow discharge deposition method to control protein adsorption ［J］. Biomaterials, 2008,29(10):1356-1366.
［12］Dhandayuthapani B, Varghese SH, Aswathy RG, et al. Evaluation of Antithrombogenicity and Hydrophilicity on ZeinSWCNT Electrospun Fibrous Nanocomposite Scaffolds ［J］. Int J Biomater, 2012,2(8):1155-1165.
［13］Weaver JD, Ku DN. Biomaterial testing for covered stent membranes: evaluating thrombosis and restenosis potential ［J］. Biomed Mater Res B Appl Biomater, 2012,100(1):103-110.
［14］梁晔,刘万顺,韩宝芹,等.一种新型生物交联剂的制备及其性质［J］.中国海洋大学学报,2008,38（4): 590-594.
［15］Gao Chunmei,Liu Mingzhu, Chen Jun, et al. Interactions between bovine serum albumin and oxidized sodium alginate in solution ［J］. Biomater Sci Polym Ed, 2011,22(12):1639-1650.
［16］Andersson LO, Hoffman J, Holmer E, et al. Mechanisms of anticoagulant effects of some sulphated polysaccharides ［J］. Thromb Res, 1982,28(6):741-748.
［17］Manju S, Muraleedharan CV, Rajeev A, et al. Evaluation of alginate dialdehyde crosslinked gelatin hydrogel as a biodegradable sealant for polyester vascular graft ［J］. Biomed Mater Res B Appl Biomater, 2011,98(1):139-149.