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| Cryoablation Combined with Immunotherapy: Maximizing Anti-Tumor Effects |
| Huang Ruotong, Lui Baolin#* |
| (Institute of Biothermal and Technology,University of Shanghai for Science and Technology, Shanghai 200093, China) |
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Abstract In recent years, energy therapy-based tumor ablation techniques have become more widely used. Among them, the cryoablation technique can effectively destroy tumors by rapid cooling of the probe, and the tumor mass left in situ would release a lot of antigens to activate immune cells, inducing the generation of anti-tumor immune responses. However, the immune response triggered by cryoablation is subjected to its conditional setting, and the intensity and sustainability of the immune response are insufficient to suppress tumor recurrence and the growth of metastases. Hence, this review focuses on the mechanisms of cryoablation for tumors, including direct cell injury, vascular injury, and immunomodulation, in which immunomodulation has a significant impact on the favorable prognosis of tumor therapy. Cryoablation factors affecting immune efficacy were further introduced to discuss the optimal conditions for generating immune response after treatment. The research progress of cryoablation combined with immunotherapy is summarized to propose new strategies for tumor treatment.
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Received: 14 June 2022
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Corresponding Authors:
* E-mail:blliuk@usst.edu.cn
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| About author:: # Member, Chinese Society of Biomedical Engineering |
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