磁性纳米颗粒的产热机制及在肿瘤热疗中的应用

doi:10.3969/j.issn.0258-8021.2021.05.12

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Abstract Magnetic hyperthermia is a new non-invasive tumor therapy following radiotherapy and chemotherapy, in which, magnetic nanoparticles were targeted delivered to the lesion sites under the applied magnetic fields and generated heat rapidly in the alternating magnetic fields. Magnetic hyperthermia made the protein denaturation, DNA damage or immune system activation in tumor microenvironment, which killed tumor cells safely and effectively in a short time. This paper reviewed the heat generation mechanisms of magnetic nanoparticles, the interactions of magnetic nanoparticles and cells in tumor therapy progress, and the synergistic effects between magnetic hyperthermia and other tumor therapies, such as chemotherapy, radiotherapy, photodynamic therapy, immune therapy. The biosafety of magnetic nanomaterials was also discussed from the aspects of cytotoxicity and clinical side effects.

Key words： magnetic hyperthermia magnetic nanoparticles heat generation mechanism tumor thermotherapy

Received: 27 July 2020

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R318

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	Articles by authors
	Xie Liqin
	Zuo Xirui
	Zhang Nan
	Chen Hongli
	Zhang Qiqing

Cite this article:

Xie Liqin,Zuo Xirui,Zhang Nan, et al. Heat Generation Mechanism of Magnetic Nanoparticles and their Applications in Tumor Thermotherapy[J]. Chinese Journal of Biomedical Engineering, 2021, 40(5): 608-619.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2021.05.12 OR http://cjbme.csbme.org/EN/Y2021/V40/I5/608

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