Preparation and Hydrophilic Characterization of Monodispersed PEG-b-PCL/ PCL Microspheres by Electrospraying
Yang Xue, Shao Huaying, Zhang Qiongyue, Wu Xiaohong*
Department of Prosthodontics, Affiliated Hosptital of Stomatology, Chongqing Medical University, Chongqing Key Laboratory ofOral Diseases and Biomedical Sciences, Chongqing 401147, China
Abstract：This study is aimed to prepare monodispersed and hydrophilic microspheres with Poly(ethylene glycol)-b-poly (ε-caprolactone) / Polycaprolactone (PEG-b-PCL/PCL) by electrospraying. PEG-b-PCL and PCL was dissolved in chloroform to prepare a mixture solution, which was magnetically stirred for 3 hours. The influence of the content of PEG-b-PCL, flow rateand the voltage of the electrospraying on the morphology, size, and size distribution of microspheres were investigated, The influence of PEG-b-PCL on hydrophilicity of microspheres and the dispersion of the microspheres in water was investigated. Monodispersed spherical microspheres with average particle sizes ranging from 5 to 6 μm and the coefficient of variation ranging from 15%～21% could be fabricated when the content of PEG-b-PCL was 10%～20%, flow rate was 1mL/h, and voltage was 10 kV. Microspheres along with fibers could be fabricated when the content of PEG-b-PCL was 30%. The contact angle of the microspheres decreased from 126.2°±4.8° to 29.9°±4.9° when the content of PEG-b-PCL was increased from 0 to 20%, and the differences showed statistical significance (P<0.05), indicating that changing the content of PEG-b-PCL could improve the hydrophilicity of the microspheres. In the meantime, microspheres with 10%～20% of PEG-b-PCL could form homogeneous dispersions in water. Conclusion: Monodispersed microspheres with improved hydrophilicity could be fabricated with PEG-b-PCL/PCL, which would be a foundation for further research on hydrophilic drug-loaded microspheres.
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