3D打印微针生物传感器用于连续血糖监测的应用进展

doi:10.3969/j.issn.0258-8021.2025.04.011

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摘要糖尿病是一种以慢性高血糖为特征的代谢性疾病,而连续血糖监测对于强化糖尿病管理以及支持相关研究具有重要意义。基于微针技术的生物传感器是一种新兴的血糖监测手段,具有无痛和可实时持续监测的优势。然而,传统微针制造技术,如微成型技术,存在制造精度低且不可定制等局限。3D打印凭借其高精度、定制化以及可选材料丰富等特点,成为制造微针的新途径。综述3D打印微针的相关应用,包括关键技术、打印原理、打印材料以及应用领域等内容;阐述微针生物传感器在连续血糖监测中的应用进展,包括工作原理、微针制备、电化学性能表征和可穿戴集成技术等要点;探讨3D打印微针面临的研发难题以及展望了微针生物传感器的未来发展方向。

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	刘俊
	樊凯
	姚丹语
	干开丰
	苏畅
	王玲
	徐铭恩

关键词 ： 3D打印微针, 微针生物传感器, 连续血糖监测

Abstract：Diabetes is a metabolic disease characterized by chronic hyperglycemia. Continuous glucose monitoring is a crucial component in the management of diabetes. Microneedle technology is an emerging method for blood glucose monitoring, which offers significant advantages such as painless, continuous, and real-time monitoring. Traditional microneedle manufacturing techniques, such as micromolding, have limitations including lower precision and lack of customizability. 3D printing technology, with its high precision, customization, and material versatility, has emerged as a new approach for microneedle fabrication. This review summarized the latest advancements in 3D printed microneedles, covering key technologies, printing principles, printable materials, and medical applications. We discussed the progress of microneedle-based glucose sensors in continuous glucose monitoring, including the underlying principles, microneedle preparation, electrochemical performance characterization, and wearable integration technologies. Finally, this review explored the challenges of 3D printed microneedles, along with future directions for the development of microneedle biosensors.

Key words： 3D printed microneedles microneedle biosensors continuous glucose monitoring

收稿日期: 2024-08-06

PACS:

R318

基金资助:科技部国家重点研发计划(2022YFA1104600,2022YFA1200208);浙江省重点研发计划项目(2022C01123)

通讯作者: ^*E-mail: xumingen@hdu.edu.cn

引用本文:

刘俊, 樊凯, 姚丹语, 干开丰, 苏畅, 王玲, 徐铭恩. 3D打印微针生物传感器用于连续血糖监测的应用进展[J]. 中国生物医学工程学报, 2025, 44(4): 494-501.
Liu Jun, Fan Kai, Yao Danyu, Gan Kaifeng, SuChang, Wang Ling, Xu Mingen. Advances in the Application of 3D Printed Microneedle Biosensor for Continuous Glucose Monitoring. Chinese Journal of Biomedical Engineering, 2025, 44(4): 494-501.

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http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2025.04.011 或 http://cjbme.csbme.org/CN/Y2025/V44/I4/494

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