Antibacterial Mechanism of Antibacterial Peptide and its Application in Local Anti-InfectionTreatment of Diabetes Foot Ulcer
Zhang Zeyu1, Liu Yufei1, Zhou Jie1, Liu Xiangsheng1, Xu Jun2, Wang Shufang1#*
1(Key Laboratory of Bioactive Materials for Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China) 2(Tianjin Medical University Chu Hisen-I Memorial Hospital, Tianjin 300134, China)
Abstract：Infectious diseases caused by pathogenic microorganisms can cause inflammation and tissue damage, which slow down the healing process, especially for chronic wounds such as diabetic feet and traumatic ulcers. Patients often suffer from impaired immune function combining with factors such as vascular disease and neuropathy around the wound surface. Therefore, bacteria are prone to multiply in the infected wound site and form biofilms, thus making it difficult for bacteria to be removed, increasing the severity of trauma site infection, and seriously affecting the subsequent life of patients. Antimicrobial peptides, as a class of active small molecule polypeptides, can achieve broad-spectrum antibacterial effect by destroying bacterial cell membrane and other methods. Some antimicrobial peptides can inhibit or destroy biofilms by inhibiting bacterial adhesion, interfering with the formation of biofilm components and interfering with bacterial quorum sensing. Combined with anti-inflammatory, immunomodulatory and other multi-functions, the peptides have been widely used in the treatment of anti-infection and chronic trauma. This review introdced antibacterial and anti-biofilm mechanisms and summarized applications of the antimicrobial peptides in anti-infection treatments of diabetic foot ulcers, and analyzed the advantages and disadvantages of the various applications. Accordingly, development prospects of the antimicrobial peptides were proposed, aiming to provide practical approaches for the anti-infection treatment of diabetic foot ulcers.
张泽宇, 刘语菲, 周洁, 刘祥胜, 徐俊, 王淑芳. 抗菌肽抗菌机理及其在糖尿病足溃疡局部抗感染治疗中的应用[J]. 中国生物医学工程学报, 2024, 43(6): 751-758.
Zhang Zeyu, Liu Yufei, Zhou Jie, Liu Xiangsheng, Xu Jun, Wang Shufang. Antibacterial Mechanism of Antibacterial Peptide and its Application in Local Anti-InfectionTreatment of Diabetes Foot Ulcer. Chinese Journal of Biomedical Engineering, 2024, 43(6): 751-758.
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