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中国生物医学工程学报  2024, Vol. 43 Issue (6): 751-758    DOI: 10.3969/j.issn.0258-8021.2024.06.012
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抗菌肽抗菌机理及其在糖尿病足溃疡局部抗感染治疗中的应用
张泽宇1, 刘语菲1, 周洁1, 刘祥胜1, 徐俊2, 王淑芳1#*
1(南开大学生命科学学院,生物活性材料教育部重点实验室,天津 300071)
2(天津医科大学朱宪彝纪念医院糖尿病足科,天津 300134)
Antibacterial Mechanism of Antibacterial Peptide and its Application in Local Anti-InfectionTreatment of Diabetes Foot Ulcer
Zhang Zeyu1, Liu Yufei1, Zhou Jie1, Liu Xiangsheng1, Xu Jun2, Wang Shufang1#*
1(Key Laboratory of Bioactive Materials for Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China)
2(Tianjin Medical University Chu Hisen-I Memorial Hospital, Tianjin 300134, China)
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摘要 由病原微生物引起的感染性疾病常导致炎症和组织损伤,减缓愈合过程。对于慢性创伤,尤其是糖尿病足溃疡,患者常因免疫功能受损,以及伴有创面出现外周血管病变和神经病变等症状,细菌易在感染创伤部位繁殖并形成生物膜,致使细菌难以清除,加重创伤部位受感染程度,严重影响创伤愈合及患者生活质量,因此迫切需要新的抗菌策略。抗菌肽提供了很有前景的抗菌模式,它作为一类活性小分子多肽,具有广谱且非特异的抗菌效果,能通过破坏细菌细胞膜等方式发挥抗菌作用;更为独特的是抗菌肽能够抑制或破坏生物膜,可实现抑制细菌黏附,干预生物膜组分的形成,并干扰细菌群体感应系统。此外,抗菌肽还具有抗炎和免疫调节等多种功能,因此在抗局部感染和糖尿病足溃疡治疗中得到广泛应用。概述了抗菌肽的抗菌和抗生物膜的机理,总结了其在糖尿病足溃疡局部抗感染治疗中的研究和应用成果,剖析了对于抗菌肽在各种应用形式中所表现的优势与不足,并展望了抗菌肽的研究和应用前景,旨在为抗菌肽在糖尿病足溃疡局部抗感染治疗提供实用的参考与建议。
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张泽宇
刘语菲
周洁
刘祥胜
徐俊
王淑芳
关键词 抗菌肽抗局部感染抗生物膜慢性创面愈合    
Abstract:Infectious diseases caused by pathogenic microorganisms can cause inflammation and tissue damage, which slow down the healing process, especially for chronic wounds such as diabetic feet and traumatic ulcers. Patients often suffer from impaired immune function combining with factors such as vascular disease and neuropathy around the wound surface. Therefore, bacteria are prone to multiply in the infected wound site and form biofilms, thus making it difficult for bacteria to be removed, increasing the severity of trauma site infection, and seriously affecting the subsequent life of patients. Antimicrobial peptides, as a class of active small molecule polypeptides, can achieve broad-spectrum antibacterial effect by destroying bacterial cell membrane and other methods. Some antimicrobial peptides can inhibit or destroy biofilms by inhibiting bacterial adhesion, interfering with the formation of biofilm components and interfering with bacterial quorum sensing. Combined with anti-inflammatory, immunomodulatory and other multi-functions, the peptides have been widely used in the treatment of anti-infection and chronic trauma. This review introdced antibacterial and anti-biofilm mechanisms and summarized applications of the antimicrobial peptides in anti-infection treatments of diabetic foot ulcers, and analyzed the advantages and disadvantages of the various applications. Accordingly, development prospects of the antimicrobial peptides were proposed, aiming to provide practical approaches for the anti-infection treatment of diabetic foot ulcers.
Key wordsantimicrobial peptides    anti-infection    anti-biofilm    chronic wound healing
收稿日期: 2023-05-06     
PACS:  R318  
基金资助:科技部重大专项(2020YFA0803701);天津市重点项目(20YFZCSY01020,S22ZDF291)
通讯作者: *E-mail: wangshufang@nankai.edu.cn   
作者简介: #中国生物医学工程学会会员
引用本文:   
张泽宇, 刘语菲, 周洁, 刘祥胜, 徐俊, 王淑芳. 抗菌肽抗菌机理及其在糖尿病足溃疡局部抗感染治疗中的应用[J]. 中国生物医学工程学报, 2024, 43(6): 751-758.
Zhang Zeyu, Liu Yufei, Zhou Jie, Liu Xiangsheng, Xu Jun, Wang Shufang. Antibacterial Mechanism of Antibacterial Peptide and its Application in Local Anti-InfectionTreatment of Diabetes Foot Ulcer. Chinese Journal of Biomedical Engineering, 2024, 43(6): 751-758.
链接本文:  
http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2024.06.012     或     http://cjbme.csbme.org/CN/Y2024/V43/I6/751
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