Applications of Spectrum Analysis Technology Based on Time-Domain Photoacoustic Signalin Biomedical Field
Zheng Jiaxin1, Tian Rui1, Liu Mingqing1, Zan Kehua1, Wang Yihan1,2*, Zhu Shouping1,2
1(School of Life Science and Technology, Xidian University, Xi′an 710126, China) 2(Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, Xidian University, Xi′an 710126, China)
Abstract：Time-domain photoacoustic (PA) signal measurement and spectral analysis technique is a non-invasive detection method that can provide the structural and functional information of biological tissue. Combining with the high contrast of optical modality and the high resolution of ultrasonic modality in deep tissue, PA signal data sets of target tissues under different wavelengths of light excitation are processed and analyzed. Compared with the conventional spectral detection, this technique is less susceptible to the limitations of the shape and morphology of the object to be measured and is not affected by the light scattering, therefore has a high sensitivity for the detection of deep tissues. In contrast to photoacoustic imaging, this technique does not require image reconstruction and focuses on achieving quantitative analysis. This article summarized the applications of time-domain PA signal spectral analysis technique in the detection of biological tissue, biological fluid, and biological exhaled gas, and reviewed the research progress and development directions of this technique around the improved experimental systems or different signal processing methods used in various studies.
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