Abstract：Titanium and its alloys are often used as orthopedic implant materials because of their stable chemical properties and good human affinity. However, untreated titanium implants are prone to poor osseointegration and infection, resulting in implantation failure. In recent years, the aging of population has led to an increase in the use of implant materials, and there is an urgent need for better titanium surface modification methods to reduce the implant failure rate. The ideal orthopedic implant should have both osteogenic and antibacterial properties. However, a large number of surface modification strategies only solve one of the problems, resulting in unexpected results. Therefore, the implant material coating needs to possess both two properties or find a balance between them. This review summarized the latest strategies to solve the problem of aseptic loosening or infection of titanium implants in recent years, such as surface morphology improvement, biomolecule coatings, antimicrobial loading, photothermal therapy and so on. Then, we further introduced the research progress of solving these two problems at the same time through two-factor integration and three-factor integration.
陆肖璇, 张露露, 阳曦, 陈佳龙. 钛植入物促骨整合及抗感染涂层的研究进展[J]. 中国生物医学工程学报, 2021, 40(5): 620-627.
Lu Xiaoxuan, Zhang Lulu, Yang Xi, Chen Jialong. Research Advancements of Coatings of Titanium Implants in Promoting Osseointegration and Preventing Infection. Chinese Journal of Biomedical Engineering, 2021, 40(5): 620-627.
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