Regulation and Mechanism of Ultrasound Bubble Technology on Tumor Microenvironment
Xu Wenqi1, Yan Yifei2, Wang Shiwei1, Xu Heyang1, Chen Tiandong1, Yang Fang1*
1(State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210018, China) 2(School of Life Science and Technology, Southeast University, Nanjing 210018, China)
Abstract：Tumor blood vessels have an important impact on tumor growth and development as an important part of the tumor microenvironment and can induce tumor resistance to treatment as a key factor in tumor metastasis. The complex and variable heterogeneity of tumor blood vessels poses significant challenges to tumor imaging and treatment. Ultrasonic bubble technology is a relatively new treatment method based on micro/nanobubbles and ultrasound. Compared with traditional treatment methods, ultrasonic bubble technology has advantages of being non-invasive and more accurate, which can improve the tumor blood vessels and effectively treat the tumors. In recent years, this technology has shown great potential in tumor therapy and diagnosis, especially in the regulation of tumor microenvironment. This review aimed to discuss effects and mechanisms of ultrasound bubble technology on tumor blood vessels, and analyzed the different mechanisms in tumor vascular therapy applications. Furthermore, this review proposed promising prospects for the future of ultrasound bubble technology as a tool to modulate the tumor microenvironment.
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