Application of Near-Infrared Fluorescence Photothermal Nanoparticles in Photothermal Therapy of Cervical Cancer
Zhu Lijun1,2#, Xiong Jiabao1,2, Du Zhong1,2, Ma Rong3, Zhang Xueliang2, Nuernisha Alifu1,2#*
1(The Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine, Xinjiang Medical University, Urumqi 830054, China) 2(School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, China) 3(Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China)
Abstract：Diagnosis and treatment of cervical cancer are of great significance to improve the survival rate and prognosis of patients. With the rapid development of nanomedicine in disease theranostics systems, near-infrared (NIR) fluorescence and photothermal therapy (PTT) based on fluorescent nanomaterials have provided promising solutions to improve the poor sensitivity, significant side effects and high incidence of postoperative metastasis in the diagnosis and treatment of cervical cancer. In this article, we reviewed the characteristics of bio-modified nanoparticles from NIR imaging and PTT, elaborated on the application of biologically modification new photothermal nanomaterials in the PTT of cervical cancer with the non-invasive, rapid, precise diagnosis and treatment, and low toxic side effects as the characteristic. Potentials of NIR imaging assisted PTT in preclinical research and clinical translation were discussed as well. Meanwhile, new NIR-photothermal nanoparticles and their preclinical experimental basis for translation to clinical treatment of cervical cancer were briefly introduced.
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