The Large-Scale Brain Network Dysfunction of Juvenile Myoclonus Epilepsy Patients
Ke Ming1*, Cui Jiping1, Liu Guangyao2*
1(College of Computer and Communication, Lanzhou University of Technology, Lanzhou 730050, China) 2(Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730030, China)
Abstract：Resting-state functional magnetic resonance imaging (fMRI) data were used to investigate the changes of large-scale brain networks in juvenile myoclonus epilepsy (JME) patients. The brain rs-fMRI data of 17 JME patients and 15 normal volunteers were collected. The partial correlation coefficient was used to construct resting state brain networks in both groups. Thresholds were independently calculated for the JME group and the normal control group. A binary brain network was built. The betweenness values of each brain region of the two groups were calculated. Two-sample T test was used to compare the differences in the betweenness values of brain network between the two groups (Bonferroni correction, P<0.01). The brain regions with significant changes of betweenness values were identified. The brain network was constructed by the partial correlation coefficient, and the brain network showed small-world property. The betweenness values of brain regions of JME patients group was significantly different from that of normal control group. Compared with the normal control group, in the JME patient group, there were 2 brain regions with significantly lower betweenness values and 17 brain regions with significantly higher betweenness values. Among them, 8 brain regions belong to the default mode network (DMN), and 5 brain regions belong to the salience network (SN). The betweenness values of the right paracentral lobule and the right posterior cingulate gyrus were significantly reduced in JME group. The regions of significantly increased betweenness values were mainly distributed in the right dorsolateral superior frontal gyrus, the left middle occipital gyrus, the right precuneus, the right lingual gyrus. The brain regions where the betweenness value of JME patients had significantly changed mainly belong to the default mode network and the salience network. It can be inferred that the connections between internal brain regions had changed in default mode network and salience network separately. These changes showed that JME patients' brain functions had been influenced and changed, resulting in impaired cognitive and executive functions.
柯铭, 崔吉平, 刘光耀. 青少年肌阵挛癫痫患者的大尺度脑网络研究[J]. 中国生物医学工程学报, 2022, 41(3): 282-289.
Ke Ming, Cui Jiping, Liu Guangyao. The Large-Scale Brain Network Dysfunction of Juvenile Myoclonus Epilepsy Patients. Chinese Journal of Biomedical Engineering, 2022, 41(3): 282-289.
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