Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation with Inter-Train Intervals on Power Spectral Density in Bilateral Motor Regions
Jin Jingna1, Liao Wenqing1, Liu Wenbo2, Wang Xin1, Liu Zhipeng1, Yin Tao1,3#*
1(Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China) 2(Sinocation (Beijing) Medical Technology Co., Ltd, Beijing 102629, China) 3(Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730, China)
Abstract：The effect of inter-train intervals incorporated into high-frequency repetitive transcranial magnetic stimulation (rTMS) on the activity of motor cortex has not been studied adequately yet. The purpose of this study was to investigate the effects of different inter-train intervals (ITI) high-frequency rTMS over primary motor cortex on neural activity energy. Eleven healthy subjects participated in real 10 Hz rTMS with 25, 50 and 100 s ITI and sham 10 Hz rTMS, with trains of 5 s duration. Electroencephalography (EEG) signals with eyes closed in resting state before and after each rTMS session were collected to analyze the changes of power spectral density and its laterality index in total, delta, theta, alpha, beta, gamma 1 and gamma 2 frequency bands in bilateral motor regions. The power spectrum density of stimulated motor cortex in all frequency bands didn’t change significantly after 25 s ITI rTMS (P>0.05). However, the power spectral density of stimulated motor cortex in theta (before vs after (11.42±1.01) dB vs (12.19±1.10) dB) and beta (before vs after (10.71±0.99) dB vs (11.20±0.88) dB) frequency bands increased, and in gamma 2 (before vs after (4.94±0.97) dB vs (3.35±0.61) dB) frequency band decreased significantly after 50 s ITI rTMS (P<0.05). The power spectral density of stimulated motor cortex in theta (before vs after (11.29±1.00) dB vs (12.17±1.10) dB), alpha (before vs after (16.17±1.20) dB vs (17.74±1.20) dB) and beta (before vs after (10.55±0.88) dB vs (11.26±0.90) dB) bands increased significantly after 100 s ITI rTMS. (P<0.05). The changes of power spectrum in non-stimulated motor cortex were similar to that in stimulated motor region. Furthermore, the laterality index of power spectral density in all frequency bands between motor cortex didn’t change after all rTMS (P>0.05). The study demonstrated that the effects of high frequency rTMS with different ITI on the motor cortex activities were different and suggested the ITI should be carefully considered when formulating the high frequency rTMS paradigms.
靳静娜, 廖文清, 刘文博, 王欣, 刘志朋, 殷涛. 不同序列间隔高频重复经颅磁刺激对运动区功率谱密度的影响[J]. 中国生物医学工程学报, 2021, 40(2): 137-144.
Jin Jingna, Liao Wenqing, Liu Wenbo, Wang Xin, Liu Zhipeng, Yin Tao. Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation with Inter-Train Intervals on Power Spectral Density in Bilateral Motor Regions. Chinese Journal of Biomedical Engineering, 2021, 40(2): 137-144.
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