Comparisons Between Molecular Features of Dilated and Restrictive Cardiomyopathy Based on Gene Co-Expression Network Analysis
Li Sang1,2,Wang Guangbin1,2,Li Zhengwen1,2,Zeng Wei1,2,Rao Nini1,2,3*
1(Center for Information Biology, University of Electronic Science and Technology of China, Chengdu 611731, China) 2(School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China) 3(Guangdong Electronic Information Engineering Research Institute, University of Electronic Science and Technology of China, Dongguan 523808, Guangdong,China)
Abstract：With the development of molecular biology, the study on dilated cardiomyopathy (DCM) and restrictive cardiomyopathy (RCM) has been made much progress. However, the pathogenesis and molecular mechanism of progression of DCM and RCM are not yet clear. In clinic, RCM is easy to be misdiagnosed as DCM. This paper firstly made the difference significant analysis of RNA-Seq data for the two kinds of myocardial diseases, from which 451 and 1326 differentially expressed genes related to DCM and RCM were selected respectively. Then, the DCM and RCM co-expression networks were respectively constructed using their differentially expressed genes and the key nodes genes of the two classes of myocardial diseases were found based on the network features. Next, we performed biological function analysis for 21 and 65 genetic markers related to DCM and RCM respectively, and illustrated some important development mechanisms of the two kinds of myocardial diseases. Finally, DCM and RCM were compared from the angles of genetic markers, biological functions and signal pathways, which provided some new ideas about distinguishing DCM from RCM at molecular level.
黎桑,王光斌,李政文,曾伟,饶妮妮. 基于基因共表达网络分析的扩张和限制型心肌病分子特征比较[J]. 中国生物医学工程学报, 2018, 37(5): 560-567.
Li Sang,Wang Guangbin,Li Zhengwen,Zeng Wei,Rao Nini. Comparisons Between Molecular Features of Dilated and Restrictive Cardiomyopathy Based on Gene Co-Expression Network Analysis. Chinese Journal of Biomedical Engineering, 2018, 37(5): 560-567.
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