The Effect of Macrophages on the Post-Implantation Reaction of Biomaterials and Tissue Regeneration
Shi Jie, Tang Di Gao, Jingchen, Kong Deling, Wang Shufang*
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
Abstract：There is a growing demand for biomaterials in clinical therapeutics. The implantation of biomaterials might end up in failure due to post-implantation inflammation. An effective approach to induce tissue regeneration would be the modulation of the macrophages responses to the implanted biomaterials. This review summaried the origin, subtypes, expression markers and functions of macrophages. Meanwhile strategies to induce macrophages toward the role of alleviating inflammation and promoting tissue regeneration after biomaterials implantation were introduced comprehensively. Some noteworthy challenges and directions in the research on facilitating tissue regeneration through the modulation of macrophages were discussed as well.
史杰, 唐笛, 高靖辰, 孔德领, 王淑芳. 巨噬细胞在生物材料植入反应及组织再生中的作用[J]. 中国生物医学工程学报, 2017, 36(6): 749-754.
Shi Jie, Tang Di Gao, Jingchen, Kong Deling, Wang Shufang. The Effect of Macrophages on the Post-Implantation Reaction of Biomaterials and Tissue Regeneration. Chinese Journal of Biomedical Engineering, 2017, 36(6): 749-754.
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