Preparation and Characterization of PSF Hollow Fiber Hemodialysis Membrane
Pan Zhenqiang1, Ma Xiaohua1, Xu Zhenliang1*, Jiang Banghe2
1(State Key Laboratory of Chemical Engineering, Shanghai Key Laboratory of Multiphase Structural Materials, Membrane Science and Engineering R&D Lab, Chemical Engineering Research Center, East China University of Science and Technology, Shanghai 200237, China) 2(Huachang Polymers L.L.C, Shanghai 200237, China)
Abstract：A novel hollow fiber hemodialysis membrane was fabricated for medical applications. The polysulfone(PSF) membrane was prepared by nonsolvent-induced phase separation (NIPS) method using diethylene glycol (DEG) as the pore former, polyvinyl pyrrolidone (PVP-K30) as the modification agent and dimethylacetamide (DMAC) as a solvent. The effect of PSF content on the morphology, permeation performance,hydrophilicity and mechanical strength of the prepared PSF membranes was characterized by scanning electron microscopy (SEM), dialysis test, contact angle, porosity and tensile test, respectively. In order to test the effects of membrane dialysis properties, the dialysis tests were conducted by using the simulated solutions containing creatine, phosphate and VB12. The pore size and molecular weight cut-off(MWCO) were obtained from the rejections of the different PEG molecular weights (MW 1 000,2 000, 4 000, 6 000, 10 000, 20 000) in the ultrafiltration experiment. The experimental results showed that the optimal mass fraction of the casting solutions was following: 21% for PSF, 10% for DEG and 10%for PVP. The ultrafiltration coefficient, break strength, pore size and MWCO of the membrane reached 185.1mL/m2·h·mmHg, 5.22 MPa, 5.00nm and14 200, respectively. Besides, the membrane also had ideal clearance of solutes for creatine, phosphate and VB12. The good permeability performance and the excellent mechanical property were suitable for hemodialysis.
[1] 郭丽艳. 老年尿毒症患者血液透析的护理[J]. 中外健康文摘,2012,9(17):369-370. [2] 石磊. 不同透析膜材料在维持性血液透析过程中的生物相容性[J]. 中国组织工程研究与临床康复,2010,14(34):6453-6456. [3] 于金刚,蒋新宇,焦飞鹏,等. 血液透析膜的应用及其改性研究进展[J].科技导报,2013,31(5):98-105. [4] Liu Min,Wei Yongming,Xu Zhenliang,et al. Preparation and characterization of polyethersulfone microporous membrane via thermally induced phase separation with low critical solution temperature system [J]. J Membr Sci,2013,437:169-178. [5] Zhang Pingyun, Wang Yanli, Xu Zhenliang. Preparation of poly(vinyl butyral) hollow fiber ultrafiltration membrane via wet-spinning method using PVP as additive[J].Desalination,2011,278(1-3): 186-193. [6] Dahe GJ,Teotia RS,Kadam SS. The biocompatibility and separation performance of antioxidative polysulfone/vitamin E TPGS composite hollow fiber membranes [J]. Biomaterials, 2011, 32(2):352-365. [7] Wang Kaiyu, Matsuura T, Chung TS, et al. The effects of flow angle and shear rate within the spinneret on the separation performance of poly(ethersulfone)(PES) ultrafiltration hollow fiber membranes[J]. J Membr Sci,2004, 240(1-2):67-79. [8] Senthilkumar S, Rajesh S, Jayalakshmi A. Preparation and performance evaluation of poly(ether-imide) incorporated polysulfone hemodialysis membrane[J]. J Polym Res, 2012, 19(6):9867-9877. [9] Zhao Longbao,Xu Zhengliang, Liu Min, et al. Preparation and characterization of PSf hollow fiber membrane from PSf-HBPE-PEG400-NMP dope solution [J].J Membr Sci,2014, 454:184-192. [10] Zhao Longbao, Liu Min, Xu Zhenliang, et al. PSF hollow fiber membrane fabricated from PSF-HBPE-PEG400-DMAc dope solutions via reverse thermally induced phase separation (RTIPS) process [J]. Chem Eng Sci, 2015, 137:131-139.
