Abstract：Coronary stent restenosis is a high incidence and severe medical event. Local hemodynamic factors, wall shear stress (WSS) in particular, critically affect the formation, progression and heterogeneity of atherosclerotic plaque. Emerging preclinical and clinical in vivo evidences now suggest that WSS may also contribute to the occurrence of stent restenosis. This review starts from the formation mechanism of instent restenosis, analyzes the mechanism of mechanical environment in coronary stent restenosis and elaborates the computational fluid dynamics (CFD) research progress in haemodynamics associated with instent restenosis in detail.
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