1 Department of Biomedicine Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University， Hangzhou 310027, China
2 ICU Department, Zhejiang Hospital, Hangzhou 310013, China
Abstract：In this paper, a heart failure (HF) treatment model based on electronic clinical guideline was proposed to realize personalized therapy. Integrated with clinical guideline of HF, a multiobjective optimization algorithm was employed to assess diseases severity and then produce individual treatment strategies. HF risk related parameters were screened and cataloged in six subclasses, i.e. cardiac structure, exercise tolerance, fluid overload, cardiac function, neural activity and electronic physiology. Accordingly, medication plans for individuals were determined. By linear weighting methods, a comprehensive index was generated to assess HF status of patients. The model was validated on 75 subjects. And the preliminary results demonstrated that the model was able to assess HF status and give treatment suggestions. In the term of agreement with the prescriptions given by physicians，the average accuracy of single drug suggested by the model was 91%. This work offered a helpful tool for facilitating individual HF treatment.
任寅姿1 傅筱1 潘清1 . 融合电子化临床指南的心力衰竭治疗决策模型[J]. 中国生物医学工程学报, 2013, 32(1): 46-52.
REN Yin Zi1FU Xiao1 PAN Qing1LIN Cheng Yu1 GONG Shi Jin2 LI Li2CAI Guo Long2 YAN Jing2* NING Gang Min
［1］Rosamond W, Flegal K, Friday G, et al. Heart disease and stroke statistics-2007 updatea report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee［J］. Circulation, 2007, 115(7) : 69-171.
［2］Stewart S, MacIntyre K, Capewell S, et al. Heart failure and the aging population: an increasing burden in the 21st century［J］. Heart, 2003, 89(1) : 49-53.
［3］Clark RA, McLennan S, Dawson A, et al. Uncovering a hidden epidemic: a study of the current burden of heart failure in Australia［J］.Heart, Lung and Circulation, 2004,13: 266-273.
［4］中华医学会心血管病学分会. 2007中国慢性心衰指南［M］. 北京: 中华心血管病杂志，2007:1-20.
［5］胡宝清. 模糊理论基础［M］. 武汉: 武汉大学出版社, 2004:5-30.
［6］王石青,王志良.确定隶属函数的统计分析法［J］. 华北水利水电学院学报, 2002,23(1):68-71.
［7］Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (writing committee to update the 2001 guidelines for the evaluation and management of heart failure): developed in collaboration with the American College of Chest Physicians and the International Society for heart and lung transplantation: endorsed by the heart rhythm society［J］. Circulation, 2005, 112(12): 154-235.
［8］Carrara WG, Goodman RS, Majewski RM. Spotlight synthetic aperture radar:signal processing algorithms［M］. Boston: Artech House, 1995: 10-35.
