Abstract：In order to deeply understand the mechanisim of heart failure and provide therapy and simulation tool for clinical diagnosis and treatment, a fifth-order lumped parameter cardiovascular system model according to electrical circuit theory was built in this paper. Using MATLAB, the simulation results show that the model is effective and it can simulate the hemodynamics of normal heart. The simulated CO (Cardiac Output) is 5.12 L/min. Under different level exercises including mild exercise, moderate exercise and severe exercise, of normal heart the simulated CO gradually increase from 5.09 L/min, 8.86 L/min, 10.74 L/min to 14.7 L/min. The four categories of ClassⅠ, ClassⅡ, ClassⅢ, Class Ⅳ of heart failure can be also simulated by the method. The simulated CO decrease from 5 L/min, 4.4 L/min, 3.8 L/min to 3.2 L/min. The results of our studies agreed well with real physiological conditions and the experimental data reported in literatures. This is important for the diagnosis and treatment of heart diseases.
刘苓苓1*李岚2 钱坤喜1. 改进型五阶集总参数心血管循环系统的建模与仿真[J]. 中国生物医学工程学报, 2012, 31(1): 13-19.
LIU LingLing1*LI Lan2 QIAN Kun Xi 1. Modeling and Simulation of a Fifth-Order Lumped Parameter Cardiovascular System. journal1, 2012, 31(1): 13-19.
