Application of Nanomedical Sensors in Tumor Marker Detection
Qin Wei1, Li Jiahui1, Chang Chunrui2*, Zhao Lijun3
1(School of Electrical Engineering, North China University of Science and Technology, Tangshan 063210, Hebei, China) 2(School of Science, North China University of Science and Technology, Tangshan 063210, Hebei, China) 3(School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, Hebei, China)
Abstract：The high mortality rate of cancer underscores the critical importance of early diagnosis, with biomarker detection serving as a pivotal approach that plays a vital role in routine physical examinations, preventive screening, recurrence monitoring, and other aspects of tumor-related healthcare. This article focuses on the applications of nanomedical sensors in tumor biomarker detection. Following a brief introduction to tumor biomarkers, medical sensors, and nanomaterials, we provided detailed discussions on biosensors based on various nanomaterials, including metallic nanoparticles, graphene, and magnetic nanoparticles, which utilize electrochemical or fluorescent signaling mechanisms. These sensors are applied to detect glycoprotein antigens, carcinoembryonic antigens, enzyme-based biomarkers, circulating tumor cells, nucleic acidsand other molecular markers. We highlighted their potential in early tumor diagnosis, disease progression monitoring, and prognostic follow-up, aiming to provide actionable insights for identifying patients′ latent malignancies and assisting clinicians in diagnosis. Looking ahead, nanomedical sensors are expected to integrate with artificial intelligence technologies to enhance detection performance, reduce costs, simplify operational workflows, and prioritize biocompatibility and safety of materials, thereby advancing the development of early-stage cancer diagnosis and treatment.
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